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Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA. Altarejos JY, et al. Among authors: dominguez gutierrez g. Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992152 Clinical Trial.
Inhibition of Aspergillus carbonarius growth and Ochratoxin A production using lactic acid bacteria cultivated in an optimized medium.
Domínguez-Gutiérrez GA, Perraud-Gaime I, Escalona-Buendía H, Durand N, Champion-Martínez EI, Fernández-Soto RR, Saucedo-Castañeda G, Rodríguez-Serrano G. Domínguez-Gutiérrez GA, et al. Int J Food Microbiol. 2023 Nov 2;404:110320. doi: 10.1016/j.ijfoodmicro.2023.110320. Epub 2023 Jul 18. Int J Food Microbiol. 2023. PMID: 37490784
Heterogeneity of human pancreatic β-cells.
Dominguez-Gutierrez G, Xin Y, Gromada J. Dominguez-Gutierrez G, et al. Mol Metab. 2019 Sep;27S(Suppl):S7-S14. doi: 10.1016/j.molmet.2019.06.015. Mol Metab. 2019. PMID: 31500834 Free PMC article. Review.
Gene Signature of the Human Pancreatic ε Cell.
Dominguez Gutierrez G, Kim J, Lee AH, Tong J, Niu J, Gray SM, Wei Y, Ding Y, Ni M, Adler C, Murphy AJ, Gromada J, Xin Y. Dominguez Gutierrez G, et al. Endocrinology. 2018 Dec 1;159(12):4023-4032. doi: 10.1210/en.2018-00833. Endocrinology. 2018. PMID: 30380031 Free PMC article.
Mice harboring the human SLC30A8 R138X loss-of-function mutation have increased insulin secretory capacity.
Kleiner S, Gomez D, Megra B, Na E, Bhavsar R, Cavino K, Xin Y, Rojas J, Dominguez-Gutierrez G, Zambrowicz B, Carrat G, Chabosseau P, Hu M, Murphy AJ, Yancopoulos GD, Rutter GA, Gromada J. Kleiner S, et al. Among authors: dominguez gutierrez g. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7642-E7649. doi: 10.1073/pnas.1721418115. Epub 2018 Jul 23. Proc Natl Acad Sci U S A. 2018. PMID: 30038024 Free PMC article.
Gene Signature of Proliferating Human Pancreatic α Cells.
Dominguez Gutierrez G, Xin Y, Okamoto H, Kim J, Lee AH, Ni M, Adler C, Yancopoulos GD, Murphy AJ, Gromada J. Dominguez Gutierrez G, et al. Endocrinology. 2018 Sep 1;159(9):3177-3186. doi: 10.1210/en.2018-00469. Endocrinology. 2018. PMID: 30010845