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Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency.
Altarejos JY, Pangilinan J, Podgrabinska S, Akinci B, Foss-Freitas M, Neidert AH, Ray Y, Zheng W, Kim S, Kamat V, Huang M, Min S, Mastaitis J, Dominguez-Gutierrez G, Kim JH, Stevis P, Huang T, Zambrowicz B, Olson WC, Godin S, Bradley E, Gewitz AD, Baker M, Hench R, Davenport MS, Chenevert TL, DiPaola F, Yancopoulos GD, Murphy AJ, Herman GA, Musser BJ, Dansky H, Harp J, Gromada J, Sleeman MW, Oral EA, Olenchock BA. Altarejos JY, et al. Sci Transl Med. 2023 Nov 22;15(723):eadd4897. doi: 10.1126/scitranslmed.add4897. Epub 2023 Nov 22. Sci Transl Med. 2023. PMID: 37992152 Clinical Trial.
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models.
Carbonaro M, Wang K, Huang H, Frleta D, Patel A, Pennington A, Desclaux M, Moller-Tank S, Grindley J, Altarejos J, Zhong J, Polites G, Poueymirou W, Jaspers S, Kyratsous C, Zambrowicz B, Murphy A, Lin JC, Macdonald LE, Daly C, Sleeman M, Thurston G, Li Z. Carbonaro M, et al. Sci Adv. 2023 Apr 14;9(15):eadf4490. doi: 10.1126/sciadv.adf4490. Epub 2023 Apr 14. Sci Adv. 2023. PMID: 37058568 Free PMC article.
Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis.
Zhou Y, Zhao Y, Carbonaro M, Chen H, Germino M, Adler C, Ni M, Zhu YO, Kim SY, Altarejos J, Li Z, Burczynski ME, Glass DJ, Sleeman MW, Lee AH, Halasz G, Cheng X. Zhou Y, et al. Metabolism. 2024 May;154:155830. doi: 10.1016/j.metabol.2024.155830. Epub 2024 Feb 28. Metabolism. 2024. PMID: 38428673
Gene expression atlas of energy balance brain regions.
De Rosa MC, Glover HJ, Stratigopoulos G, LeDuc CA, Su Q, Shen Y, Sleeman MW, Chung WK, Leibel RL, Altarejos JY, Doege CA. De Rosa MC, et al. Among authors: altarejos jy. JCI Insight. 2021 Aug 23;6(16):e149137. doi: 10.1172/jci.insight.149137. JCI Insight. 2021. PMID: 34283813 Free PMC article.
TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
Qi L, Heredia JE, Altarejos JY, Screaton R, Goebel N, Niessen S, Macleod IX, Liew CW, Kulkarni RN, Bain J, Newgard C, Nelson M, Evans RM, Yates J, Montminy M. Qi L, et al. Among authors: altarejos jy. Science. 2006 Jun 23;312(5781):1763-6. doi: 10.1126/science.1123374. Science. 2006. PMID: 16794074
15 results