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Development of fluorine-substituted NH2-biphenyl-diarylpyrimidines as highly potent non-nucleoside reverse transcriptase inhibitors: Boosting the safety and metabolic stability.
Jin X, Wang S, Zhao L, Huang W, Zhang Y, Pannecouque C, De Clercq E, Meng G, Piao H, Chen F. Jin X, et al. Among authors: de clercq e. Acta Pharm Sin B. 2023 Mar;13(3):1192-1203. doi: 10.1016/j.apsb.2022.08.017. Epub 2022 Aug 27. Acta Pharm Sin B. 2023. PMID: 36970200 Free PMC article.
Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants.
Wang Z, Zhang H, Gao Z, Sang Z, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Wang Z, et al. Among authors: de clercq e. Acta Pharm Sin B. 2024 Mar;14(3):1257-1282. doi: 10.1016/j.apsb.2023.11.023. Epub 2023 Nov 24. Acta Pharm Sin B. 2024. PMID: 38486991 Free PMC article.
2,277 results