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A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain.
Gomez K, Santiago U, Nelson TS, Allen HN, Calderon-Rivera A, Hestehave S, Rodríguez Palma EJ, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang KE, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora PS, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj MI, Korczeniewska OA, Camacho CJ, Khanna R. Gomez K, et al. Among authors: loya lopez s. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2305215120. doi: 10.1073/pnas.2305215120. Epub 2023 Nov 16. Proc Natl Acad Sci U S A. 2023. PMID: 37972067 Free PMC article.
Betulinic acid analogs inhibit N- and T-type voltage-gated calcium channels to attenuate nerve-injury associated neuropathic and formalin models of pain.
Calderon-Rivera A, Gomez K, Loya-López S, Wijeratne EMK, Stratton H, Tang C, Duran P, Masterson K, Alsbiei O, Gunatilaka AAL, Khanna R. Calderon-Rivera A, et al. Among authors: loya lopez s. Neurobiol Pain. 2023 Jan 14;13:100116. doi: 10.1016/j.ynpai.2023.100116. eCollection 2023 Jan-Jul. Neurobiol Pain. 2023. PMID: 36687466 Free PMC article.
Targeted transcriptional upregulation of SENP1 by CRISPR activation enhances deSUMOylation pathways to elicit antinociception in the spinal nerve ligation model of neuropathic pain.
Gomez K, Allen HN, Duran P, Loya-Lopez S, Calderon-Rivera A, Moutal A, Tang C, Nelson TS, Perez-Miller S, Khanna R. Gomez K, et al. Among authors: loya lopez s. Pain. 2024 Apr 1;165(4):866-883. doi: 10.1097/j.pain.0000000000003080. Epub 2023 Oct 20. Pain. 2024. PMID: 37862053
The natural product argentatin C attenuates postoperative pain via inhibition of voltage-gated sodium and T-type voltage-gated calcium channels.
Duran P, Loya-López S, Ran D, Tang C, Calderon-Rivera A, Gomez K, Stratton HJ, Huang S, Xu YM, Wijeratne EMK, Perez-Miller S, Shan Z, Cai S, Gabrielsen AT, Dorame A, Masterson KA, Alsbiei O, Madura CL, Luo G, Moutal A, Streicher J, Zamponi GW, Gunatilaka AAL, Khanna R. Duran P, et al. Br J Pharmacol. 2023 May;180(9):1267-1285. doi: 10.1111/bph.15974. Epub 2023 Jan 15. Br J Pharmacol. 2023. PMID: 36245395 Free article.
The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain.
Son GY, Tu NH, Santi MD, Loya Lopez S, Souza Bomfim GH, Vinu M, Zhou F, Chaloemtoem A, Alhariri R, Idaghdour Y, Khanna R, Ye Y, Lacruz RS. Son GY, et al. Among authors: loya lopez s. Sci Signal. 2023 Sep 5;16(801):eadf9535. doi: 10.1126/scisignal.adf9535. Epub 2023 Sep 5. Sci Signal. 2023. PMID: 37669398 Free PMC article.
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