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Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1.
Goyal N, Liu J, Lovings L, Dupart P, Taylor S, Bellow S, Mensah L, McClain E, Dotson B, Sridhar J, Zhang X, Zhao M, Foroozesh M. Goyal N, et al. Chem Res Toxicol. 2014 Aug 18;27(8):1431-9. doi: 10.1021/tx5001865. Epub 2014 Jul 29. Chem Res Toxicol. 2014. PMID: 25033111 Free PMC article.
A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.
Liu J, Pham PT, Skripnikova EV, Zheng S, Lovings LJ, Wang Y, Goyal N, Bellow SM, Mensah LM, Chatters AJ, Bratton MR, Wiese TE, Zhao M, Wang G, Foroozesh M. Liu J, et al. Among authors: goyal n. J Med Chem. 2015 Aug 27;58(16):6481-93. doi: 10.1021/acs.jmedchem.5b00494. Epub 2015 Aug 10. J Med Chem. 2015. PMID: 26222195 Free PMC article.
Identification of quinones as novel PIM1 kinase inhibitors.
Schroeder RL, Goyal N, Bratton M, Townley I, Pham NA, Tram P, Stone T, Geathers J, Nguyen K, Sridhar J. Schroeder RL, et al. Among authors: goyal n. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3187-3191. doi: 10.1016/j.bmcl.2016.04.079. Epub 2016 Apr 28. Bioorg Med Chem Lett. 2016. PMID: 27173800 Free PMC article.
Synthetic Method to Form 2,2'-Bis(naphthoquinone) Compounds.
Jha V, Goyal N, Stevens CK, Stevens E, Sridhar J. Jha V, et al. Among authors: goyal n. J Org Chem. 2017 Dec 15;82(24):13686-13692. doi: 10.1021/acs.joc.7b02501. Epub 2017 Nov 22. J Org Chem. 2017. PMID: 29111723
Ethyl 2-[2-(4-oxo-4H-chromen-2-yl)phenoxy]acetate.
Goyal N, Do C, Donahue JP, Mague JT, Foroozesh M. Goyal N, et al. IUCrdata. 2018 Jul;3(7):x180993. doi: 10.1107/S2414314618009938. IUCrdata. 2018. PMID: 30984887 Free PMC article.
Coumarins and P450s, Studies Reported to-Date.
Foroozesh M, Sridhar J, Goyal N, Liu J. Foroozesh M, et al. Among authors: goyal n. Molecules. 2019 Apr 24;24(8):1620. doi: 10.3390/molecules24081620. Molecules. 2019. PMID: 31022888 Free PMC article. Review.
1,346 results