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The regional pattern of age-related synaptic loss in the human brain differs from gray matter volume loss: in vivo PET measurement with [11C]UCB-J.
Toyonaga T, Khattar N, Wu Y, Lu Y, Naganawa M, Gallezot JD, Matuskey D, Mecca AP, Pittman B, Dias M, Nabulsi NB, Finnema SJ, Chen MK, Arnsten A, Radhakrishnan R, Skosnik PD, D'Souza DC, Esterlis I, Huang Y, van Dyck CH, Carson RE. Toyonaga T, et al. Among authors: finnema sj. Eur J Nucl Med Mol Imaging. 2024 Mar;51(4):1012-1022. doi: 10.1007/s00259-023-06487-8. Epub 2023 Nov 13. Eur J Nucl Med Mol Imaging. 2024. PMID: 37955791
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort.
Naganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca A, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. Naganawa M, et al. Among authors: finnema sj. J Nucl Med. 2021 Mar;62(3):418-421. doi: 10.2967/jnumed.120.243949. Epub 2020 Jul 9. J Nucl Med. 2021. PMID: 32646875 Free PMC article.
Comparison of [11C]UCB-J and [18F]FDG PET in Alzheimer's disease: A tracer kinetic modeling study.
Chen MK, Mecca AP, Naganawa M, Gallezot JD, Toyonaga T, Mondal J, Finnema SJ, Lin SF, O'Dell RS, McDonald JW, Michalak HR, Vander Wyk B, Nabulsi NB, Huang Y, Arnsten AF, van Dyck CH, Carson RE. Chen MK, et al. Among authors: finnema sj. J Cereb Blood Flow Metab. 2021 Sep;41(9):2395-2409. doi: 10.1177/0271678X211004312. Epub 2021 Mar 24. J Cereb Blood Flow Metab. 2021. PMID: 33757318 Free PMC article.
In vivo evidence of lower synaptic vesicle density in schizophrenia.
Radhakrishnan R, Skosnik PD, Ranganathan M, Naganawa M, Toyonaga T, Finnema S, Hillmer AT, Esterlis I, Huang Y, Nabulsi N, Carson RE, D'Souza DC. Radhakrishnan R, et al. Mol Psychiatry. 2021 Dec;26(12):7690-7698. doi: 10.1038/s41380-021-01184-0. Epub 2021 Jun 16. Mol Psychiatry. 2021. PMID: 34135473
A metabolically stable PET tracer for imaging synaptic vesicle protein 2A: synthesis and preclinical characterization of [18F]SDM-16.
Zheng C, Holden D, Zheng MQ, Pracitto R, Wilcox KC, Lindemann M, Felchner Z, Zhang L, Tong J, Fowles K, Finnema SJ, Nabulsi N, Carson RE, Huang Y, Cai Z. Zheng C, et al. Among authors: finnema sj. Eur J Nucl Med Mol Imaging. 2022 Apr;49(5):1482-1496. doi: 10.1007/s00259-021-05597-5. Epub 2021 Nov 11. Eur J Nucl Med Mol Imaging. 2022. PMID: 34761284 Free PMC article.
Imaging synaptic density in the living human brain.
Finnema SJ, Nabulsi NB, Eid T, Detyniecki K, Lin SF, Chen MK, Dhaher R, Matuskey D, Baum E, Holden D, Spencer DD, Mercier J, Hannestad J, Huang Y, Carson RE. Finnema SJ, et al. Sci Transl Med. 2016 Jul 20;8(348):348ra96. doi: 10.1126/scitranslmed.aaf6667. Sci Transl Med. 2016. PMID: 27440727 Clinical Trial.
Kinetic evaluation and test-retest reproducibility of [11C]UCB-J, a novel radioligand for positron emission tomography imaging of synaptic vesicle glycoprotein 2A in humans.
Finnema SJ, Nabulsi NB, Mercier J, Lin SF, Chen MK, Matuskey D, Gallezot JD, Henry S, Hannestad J, Huang Y, Carson RE. Finnema SJ, et al. J Cereb Blood Flow Metab. 2018 Nov;38(11):2041-2052. doi: 10.1177/0271678X17724947. Epub 2017 Aug 9. J Cereb Blood Flow Metab. 2018. PMID: 28792356 Free PMC article.
Assessing Synaptic Density in Alzheimer Disease With Synaptic Vesicle Glycoprotein 2A Positron Emission Tomographic Imaging.
Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH. Chen MK, et al. Among authors: finnema sj. JAMA Neurol. 2018 Oct 1;75(10):1215-1224. doi: 10.1001/jamaneurol.2018.1836. JAMA Neurol. 2018. PMID: 30014145 Free PMC article.
69 results