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Hippo and PI5P4K signaling intersect to control the transcriptional activation of YAP.
Palamiuc L, Johnson JL, Haratipour Z, Loughran RM, Choi WJ, Arora GK, Tieu V, Ly K, Llorente A, Crabtree S, Wong JCY, Ravi A, Wiederhold T, Murad R, Blind RD, Emerling BM. Palamiuc L, et al. Among authors: emerling bm. Sci Signal. 2024 May 28;17(838):eado6266. doi: 10.1126/scisignal.ado6266. Epub 2024 May 28. Sci Signal. 2024. PMID: 38805583
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition.
Triscott J, Reist M, Küng L, Mosele FC, Lehner M, Gallon J, Ravi A, Arora GK, de Brot S, Lundquist M, Gallart-Ayala H, Ivanisevic J, Piscuoglio S, Cantley LC, Emerling BM, Rubin MA. Triscott J, et al. Among authors: emerling bm. Sci Adv. 2023 Feb 3;9(5):eade8641. doi: 10.1126/sciadv.ade8641. Epub 2023 Feb 1. Sci Adv. 2023. PMID: 36724278 Free PMC article.
Beyond PI3Ks: targeting phosphoinositide kinases in disease.
Burke JE, Triscott J, Emerling BM, Hammond GRV. Burke JE, et al. Among authors: emerling bm. Nat Rev Drug Discov. 2023 May;22(5):357-386. doi: 10.1038/s41573-022-00582-5. Epub 2022 Nov 14. Nat Rev Drug Discov. 2023. PMID: 36376561 Free PMC article. Review.
Mechanistic roles of mutant p53 governing lipid metabolism.
Loughran RM, Emerling BM. Loughran RM, et al. Among authors: emerling bm. Adv Biol Regul. 2022 Jan;83:100839. doi: 10.1016/j.jbior.2021.100839. Epub 2021 Nov 23. Adv Biol Regul. 2022. PMID: 34840111 Free PMC article. Review.
38 results