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Discovery of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid derivative as a potent and selective heparanase-1 inhibitor utilizing an improved synthetic approach.
Imai Y, Suzuki R, Matsuda D, Tanaka-Yamamoto N, Ohki Y, Tabata R, Kato S, Sugisaki M, Fujimoto N, Fukunaga T, Kato S, Takahashi T, Kakinuma H. Imai Y, et al. Among authors: fujimoto n. Bioorg Med Chem Lett. 2024 Jan 1;97:129543. doi: 10.1016/j.bmcl.2023.129543. Epub 2023 Nov 6. Bioorg Med Chem Lett. 2024. PMID: 37939863
Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.
Imai Y, Suzuki R, Wakasugi D, Matsuda D, Tanaka-Yamamoto N, Ohki Y, Mima M, Endo M, Tabata R, Matsuzawa H, Hasegawa Y, Kato S, Sugisaki M, Miyagawa H, Fujimoto N, Fukunaga T, Kato S, Takahashi T, Kakinuma H. Imai Y, et al. Among authors: fujimoto n. Bioorg Med Chem. 2023 Oct 1;93:117460. doi: 10.1016/j.bmc.2023.117460. Epub 2023 Aug 26. Bioorg Med Chem. 2023. PMID: 37660465
[No title available]
[No authors listed] [No authors listed] PMID: 31994100
Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment.
Ochiai N, Nakachi Y, Yokoo T, Ichihara T, Eriksson T, Yonemoto Y, Kato T, Ogata H, Fujimoto N, Kobayashi Y, Udagawa N, Kaku S, Ueki T, Okazaki Y, Takahashi N, Suda T. Ochiai N, et al. Among authors: fujimoto n. Commun Biol. 2019 Mar 1;2:86. doi: 10.1038/s42003-019-0334-5. eCollection 2019. Commun Biol. 2019. PMID: 30854478 Free PMC article.
Cardiovascular Magnetic Resonance Radiomics to Identify Components of the Extracellular Matrix in Dilated Cardiomyopathy.
Nakamori S, Amyar A, Fahmy AS, Ngo LH, Ishida M, Nakamura S, Omori T, Moriwaki K, Fujimoto N, Imanaka-Yoshida K, Sakuma H, Dohi K, Manning WJ, Nezafat R. Nakamori S, et al. Among authors: fujimoto n. Circulation. 2024 May 29. doi: 10.1161/CIRCULATIONAHA.123.067107. Online ahead of print. Circulation. 2024. PMID: 38808522 Free article.
1,139 results