Laggner C - Search Results

1

A novel binding pocket in the D2 domain of protein tyrosine phosphatase mu (PTPmu) guides AI screen to identify small molecules that modulate tumour cell adhesion, growth and migration.

Molyneaux K, Laggner C, Brady-Kalnay SM. Molyneaux K, et al. Among authors: laggner c. J Cell Mol Med. 2023 Nov;27(22):3553-3564. doi: 10.1111/jcmm.17973. Epub 2023 Oct 20. J Cell Mol Med. 2023. PMID: 37860940 Free PMC article.

2

Artificial Intelligence-Based Computational Screening and Functional Assays Identify Candidate Small Molecule Antagonists of PTPmu-Dependent Adhesion.

Molyneaux K, Laggner C, Brady-Kalnay SM. Molyneaux K, et al. Among authors: laggner c. Int J Mol Sci. 2023 Feb 21;24(5):4274. doi: 10.3390/ijms24054274. Int J Mol Sci. 2023. PMID: 36901713 Free PMC article.

3

Small molecule antagonists of PTPmu identified by artificial intelligence-based computational screening block glioma cell migration and growth.

Molyneaux K, Laggner C, Vincent J, Brady-Kalnay S. Molyneaux K, et al. Among authors: laggner c. PLoS One. 2023 Jul 26;18(7):e0288980. doi: 10.1371/journal.pone.0288980. eCollection 2023. PLoS One. 2023. PMID: 37494327 Free PMC article.

4

AI is a viable alternative to high throughput screening: a 318-target study.

Atomwise AIMS Program. Atomwise AIMS Program. Sci Rep. 2024 Apr 2;14(1):7526. doi: 10.1038/s41598-024-54655-z. Sci Rep. 2024. PMID: 38565852 Free PMC article.

5

SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth.

Su S, Chen J, Jiang Y, Wang Y, Vital T, Zhang J, Laggner C, Nguyen KT, Zhu Z, Prevatte AW, Barker NK, Herring LE, Davis IJ, Liu P. Su S, et al. Among authors: laggner c. Adv Sci (Weinh). 2021 Jul;8(14):e2004846. doi: 10.1002/advs.202004846. Epub 2021 Jun 1. Adv Sci (Weinh). 2021. PMID: 34060252 Free PMC article.

6

AtomNet-Aided OTUD7B Inhibitor Discovery and Validation.

Chen J, Bolhuis DL, Laggner C, Kong D, Yu L, Wang X, Emanuele MJ, Brown NG, Liu P. Chen J, et al. Among authors: laggner c. Cancers (Basel). 2023 Jan 14;15(2):517. doi: 10.3390/cancers15020517. Cancers (Basel). 2023. PMID: 36672466 Free PMC article.

7

Not Every Hit-Identification Technique Works on 1-Deoxy-d-Xylulose 5-Phosphate Synthase (DXPS): Making the Most of a Virtual Screening Campaign.

Johannsen S, Gierse RM, Olshanova A, Smerznak E, Laggner C, Eschweiler L, Adeli Z, Hamid R, Alhayek A, Reiling N, Haupenthal J, Hirsch AKH. Johannsen S, et al. Among authors: laggner c. ChemMedChem. 2023 Jun 1;18(11):e202200590. doi: 10.1002/cmdc.202200590. Epub 2023 Apr 14. ChemMedChem. 2023. PMID: 36896721

8

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding.

Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. Lemieux GA, et al. Among authors: laggner c. PLoS Biol. 2013 Nov;11(11):e1001712. doi: 10.1371/journal.pbio.1001712. Epub 2013 Nov 19. PLoS Biol. 2013. PMID: 24260022 Free PMC article.

9

Carbamoylation abrogates the antioxidant potential of hydrogen sulfide.

Praschberger M, Hermann M, Laggner C, Jirovetz L, Exner M, Kapiotis S, Gmeiner BM, Laggner H. Praschberger M, et al. Among authors: laggner c. Biochimie. 2013 Nov;95(11):2069-75. doi: 10.1016/j.biochi.2013.07.018. Epub 2013 Jul 26. Biochimie. 2013. PMID: 23896375

10

Synthesis and biological evaluation of the 1-arylpyrazole class of σ(1) receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1H-pyrazol-3-yloxy]ethyl}morpholine (S1RA, E-52862).

Díaz JL, Cuberes R, Berrocal J, Contijoch M, Christmann U, Fernández A, Port A, Holenz J, Buschmann H, Laggner C, Serafini MT, Burgueño J, Zamanillo D, Merlos M, Vela JM, Almansa C. Díaz JL, et al. Among authors: laggner c. J Med Chem. 2012 Oct 11;55(19):8211-24. doi: 10.1021/jm3007323. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22784008

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

47 results

Search Page