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Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 Mpro Inhibitors.
ACS Med Chem Lett. 2023 Sep 28;14(10):1434-1440. doi: 10.1021/acsmedchemlett.3c00335. eCollection 2023 Oct 12.
ACS Med Chem Lett. 2023.
PMID: 37849558
Free PMC article.
Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury.
Fritzemeier RG, van der Westhuyzen AE, D'Erasmo M, Sharma SK, Bartsch P, Hodson LE, Liu K, Wali B, Sayeed I, Liotta DC.
Fritzemeier RG, et al. Among authors: van der westhuyzen ae.
J Med Chem. 2023 Apr 27;66(8):5397-5414. doi: 10.1021/acs.jmedchem.2c01484. Epub 2023 Apr 7.
J Med Chem. 2023.
PMID: 37026870
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Deciphering the chemical instability of sphaeropsidin A under physiological conditions - degradation studies and structural elucidation of the major metabolite.
van der Westhuyzen AE, Ingels A, Rosière R, Amighi K, Oberer L, Gustafson KR, Wang D, Evidente A, Maddau L, Masi M, de Villiers A, Green IR, Berger W, Kornienko A, Mathieu V, van Otterlo WAL.
van der Westhuyzen AE, et al.
Org Biomol Chem. 2020 Oct 21;18(40):8147-8160. doi: 10.1039/d0ob01586e.
Org Biomol Chem. 2020.
PMID: 33016969
Free PMC article.
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Microtubule-Targeting 7-Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug-Resistance Proteins.
Dasari R, Błauż A, Medellin DC, Kassim RM, Viera C, Santarosa M, van der Westhuyzen AE, van Otterlo WAL, Olivas T, Yildiz T, Betancourt T, Shuster CB, Rogelj S, Rychlik B, Hudnall T, Frolova LV, Kornienko A.
Dasari R, et al. Among authors: van der westhuyzen ae.
ChemMedChem. 2019 Feb 5;14(3):322-333. doi: 10.1002/cmdc.201800658. Epub 2019 Jan 25.
ChemMedChem. 2019.
PMID: 30562414
Free PMC article.
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The Rigidins: Isolation, Bioactivity, and Total Synthesis-Novel Pyrrolo[2,3-d]Pyrimidine Analogues Using Multicomponent Reactions.
van der Westhuyzen AE, Frolova LV, Kornienko A, van Otterlo WAL.
van der Westhuyzen AE, et al.
Alkaloids Chem Biol. 2018;79:191-220. doi: 10.1016/bs.alkal.2017.12.003. Epub 2018 Feb 6.
Alkaloids Chem Biol. 2018.
PMID: 29455836
Review.
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Sarniensine, a mesembrine-type alkaloid isolated from Nerine sarniensis, an indigenous South African Amaryllidaceae, with larvicidal and adulticidal activities against Aedes aegypti.
Masi M, van der Westhuyzen AE, Tabanca N, Evidente M, Cimmino A, Green IR, Bernier UR, Becnel JJ, Bloomquist JR, van Otterlo WA, Evidente A.
Masi M, et al. Among authors: van der westhuyzen ae.
Fitoterapia. 2017 Jan;116:34-38. doi: 10.1016/j.fitote.2016.11.007. Epub 2016 Nov 15.
Fitoterapia. 2017.
PMID: 27864138
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