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A kinetic ensemble of the Alzheimer's Aβ peptide.
Löhr T, Kohlhoff K, Heller GT, Camilloni C, Vendruscolo M. Löhr T, et al. Among authors: heller gt. Nat Comput Sci. 2021 Jan;1(1):71-78. doi: 10.1038/s43588-020-00003-w. Epub 2021 Jan 14. Nat Comput Sci. 2021. PMID: 38217162
A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer's disease.
Ikenoue T, Aprile FA, Sormanni P, Ruggeri FS, Perni M, Heller GT, Haas CP, Middel C, Limbocker R, Mannini B, Michaels TCT, Knowles TPJ, Dobson CM, Vendruscolo M. Ikenoue T, et al. Among authors: heller gt. Sci Rep. 2020 Sep 17;10(1):15280. doi: 10.1038/s41598-020-69626-3. Sci Rep. 2020. PMID: 32943652 Free PMC article.
Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors.
Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson CM, Vendruscolo M, Knowles TPJ. Michaels TCT, et al. Among authors: heller gt. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24251-24257. doi: 10.1073/pnas.2006684117. Epub 2020 Sep 14. Proc Natl Acad Sci U S A. 2020. PMID: 32929030 Free PMC article.
Rational design of a conformation-specific antibody for the quantification of Aβ oligomers.
Aprile FA, Sormanni P, Podpolny M, Chhangur S, Needham LM, Ruggeri FS, Perni M, Limbocker R, Heller GT, Sneideris T, Scheidt T, Mannini B, Habchi J, Lee SF, Salinas PC, Knowles TPJ, Dobson CM, Vendruscolo M. Aprile FA, et al. Among authors: heller gt. Proc Natl Acad Sci U S A. 2020 Jun 16;117(24):13509-13518. doi: 10.1073/pnas.1919464117. Epub 2020 Jun 3. Proc Natl Acad Sci U S A. 2020. PMID: 32493749 Free PMC article.
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes.
Limbocker R, Chia S, Ruggeri FS, Perni M, Cascella R, Heller GT, Meisl G, Mannini B, Habchi J, Michaels TCT, Challa PK, Ahn M, Casford ST, Fernando N, Xu CK, Kloss ND, Cohen SIA, Kumita JR, Cecchi C, Zasloff M, Linse S, Knowles TPJ, Chiti F, Vendruscolo M, Dobson CM. Limbocker R, et al. Among authors: heller gt. Nat Commun. 2019 Jan 15;10(1):225. doi: 10.1038/s41467-018-07699-5. Nat Commun. 2019. PMID: 30644384 Free PMC article.
21 results