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Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
Stepan AF, Claffey MM, Reese MR, Balan G, Barreiro G, Barricklow J, Bohanon MJ, Boscoe BP, Cappon GD, Chenard LK, Cianfrogna J, Chen L, Coffman KJ, Drozda SE, Dunetz JR, Ghosh S, Hou X, Houle C, Karki K, Lazzaro JT, Mancuso JY, Marcek JM, Miller EL, Moen MA, O'Neil S, Sakurada I, Skaddan M, Parikh V, Smith DL, Trapa P, Tuttle JB, Verhoest PR, Walker DP, Won A, Wright AS, Whritenour J, Zasadny K, Zaleska MM, Zhang L, Shaffer CL. Stepan AF, et al. Among authors: marcek jm. J Med Chem. 2017 Sep 28;60(18):7764-7780. doi: 10.1021/acs.jmedchem.7b00604. Epub 2017 Sep 13. J Med Chem. 2017. PMID: 28817277
A model comparing how rapidly transfusion of solvent detergent plasma restores clotting factors versus infusion of albumin-saline.
Jilma-Stohlawetz P, Kursten FW, Horvath M, Leitner G, List J, Marcek J, Quehenberger P, Schwameis M, Bartko J, Jilma B. Jilma-Stohlawetz P, et al. Among authors: marcek j. Transfus Apher Sci. 2015 Dec;53(3):360-7. doi: 10.1016/j.transci.2014.02.028. Epub 2015 Jul 29. Transfus Apher Sci. 2015. PMID: 26297187 Free article. Clinical Trial.
Toxicity of hydroxyurea in rats and dogs.
Morton D, Reed L, Huang W, Marcek JM, Austin-LaFrance R, Northcott CA, Schelling SH, Enerson BE, Tomlinson L. Morton D, et al. Among authors: marcek jm. Toxicol Pathol. 2015 Jun;43(4):498-512. doi: 10.1177/0192623314559103. Epub 2014 Nov 11. Toxicol Pathol. 2015. PMID: 25391310
Once versus three times daily dosing of oral budesonide for active Crohn's disease: a double-blind, double-dummy, randomised trial.
Dignass A, Stoynov S, Dorofeyev AE, Grigorieva GA, Tomsová E, Altorjay I, Tuculanu D, Bunganič I, Pokrotnieks J, Kupčinskas L, Dilger K, Greinwald R, Mueller R; International Budenofalk Study Group. Dignass A, et al. J Crohns Colitis. 2014 Sep;8(9):970-80. doi: 10.1016/j.crohns.2014.01.021. Epub 2014 Feb 15. J Crohns Colitis. 2014. PMID: 24534142 Clinical Trial.
19 results