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A global initiative to refine acute inhalation studies through the use of 'evident toxicity' as an endpoint: Towards adoption of the fixed concentration procedure.
Sewell F, Ragan I, Marczylo T, Anderson B, Braun A, Casey W, Dennison N, Griffiths D, Guest R, Holmes T, van Huygevoort T, Indans I, Kenny T, Kojima H, Lee K, Prieto P, Smith P, Smedley J, Stokes WS, Wnorowski G, Horgan G. Sewell F, et al. Among authors: ragan i. Regul Toxicol Pharmacol. 2015 Dec;73(3):770-9. doi: 10.1016/j.yrtph.2015.10.018. Epub 2015 Oct 23. Regul Toxicol Pharmacol. 2015. PMID: 26505531 Free article.
Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.
Sewell F, Chapman K, Baldrick P, Brewster D, Broadmeadow A, Brown P, Burns-Naas LA, Clarke J, Constan A, Couch J, Czupalla O, Danks A, DeGeorge J, de Haan L, Hettinger K, Hill M, Festag M, Jacobs A, Jacobson-Kram D, Kopytek S, Lorenz H, Moesgaard SG, Moore E, Pasanen M, Perry R, Ragan I, Robinson S, Schmitt PM, Short B, Lima BS, Smith D, Sparrow S, van Bekkum Y, Jones D. Sewell F, et al. Among authors: ragan i. Regul Toxicol Pharmacol. 2014 Oct;70(1):413-29. doi: 10.1016/j.yrtph.2014.07.018. Epub 2014 Jul 29. Regul Toxicol Pharmacol. 2014. PMID: 25078890 Free article.
Advancing the 3Rs in regulatory toxicology - Carcinogenicity testing: Scope for harmonisation and advancing the 3Rs in regulated sectors of the European Union.
Annys E, Billington R, Clayton R, Bremm KD, Graziano M, McKelvie J, Ragan I, Schwarz M, van der Laan JW, Wood C, Öberg M, Wester P, Woodward KN. Annys E, et al. Among authors: ragan i. Regul Toxicol Pharmacol. 2014 Jul;69(2):234-42. doi: 10.1016/j.yrtph.2014.04.009. Epub 2014 Apr 24. Regul Toxicol Pharmacol. 2014. PMID: 24768934
Opportunities for improving animal welfare in rodent models of epilepsy and seizures.
Lidster K, Jefferys JG, Blümcke I, Crunelli V, Flecknell P, Frenguelli BG, Gray WP, Kaminski R, Pitkänen A, Ragan I, Shah M, Simonato M, Trevelyan A, Volk H, Walker M, Yates N, Prescott MJ. Lidster K, et al. Among authors: ragan i. J Neurosci Methods. 2016 Feb 15;260:2-25. doi: 10.1016/j.jneumeth.2015.09.007. Epub 2015 Sep 12. J Neurosci Methods. 2016. PMID: 26376175 Free article. Review.
51 results