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Design and Synthesis of Novel 2-Acetamido, 6-Carboxamide Substituted Benzothiazoles as Potential BRAFV600E Inhibitors - In vitro Evaluation of their Antiproliferative Activity.
ChemMedChem. 2023 Nov 16;18(22):e202300322. doi: 10.1002/cmdc.202300322. Epub 2023 Oct 24.
ChemMedChem. 2023.
PMID: 37792577
BRAF paradox breakers PLX8394, PLX7904 are more effective against BRAFV600Ε CRC cells compared with the BRAF inhibitor PLX4720 and shown by detailed pathway analysis.
Koumaki K, Kontogianni G, Kosmidou V, Pahitsa F, Kritsi E, Zervou M, Chatziioannou A, Souliotis VL, Papadodima O, Pintzas A.
Koumaki K, et al.
Biochim Biophys Acta Mol Basis Dis. 2021 Apr 1;1867(4):166061. doi: 10.1016/j.bbadis.2020.166061. Epub 2020 Dec 29.
Biochim Biophys Acta Mol Basis Dis. 2021.
PMID: 33385518
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