Barbachyn MR - Search Results

1

Bacterial efflux pump modulators prevent bacterial growth in macrophages and under broth conditions that mimic the host environment.

Allgood SC, Su C-C, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. Allgood SC, et al. Among authors: barbachyn mr. mBio. 2023 Nov 3;14(6):e0249223. doi: 10.1128/mbio.02492-23. Online ahead of print. mBio. 2023. PMID: 37921493 Free PMC article.

2

Identification of a 1,2,4-Oxadiazole with Potent and Specific Activity against Clostridioides difficile, the Causative Bacterium of C. difficile Infection, an Urgent Public Health Threat.

Barbachyn MR. Barbachyn MR. J Med Chem. 2023 Oct 26;66(20):13888-13890. doi: 10.1021/acs.jmedchem.3c01778. Epub 2023 Oct 12. J Med Chem. 2023. PMID: 37823241 Free PMC article.

3

Bacterial Efflux Pump Modulators Prevent Bacterial Growth in Macrophages and Under Broth Conditions that Mimic the Host Environment.

Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS. Allgood SC, et al. Among authors: barbachyn mr. bioRxiv [Preprint]. 2023 Sep 20:2023.09.20.558466. doi: 10.1101/2023.09.20.558466. bioRxiv. 2023. PMID: 37786697 Free PMC article. Updated. Preprint.

4

The Synthesis of Functionalized 3-Aryl- and 3-Heteroaryloxazolidin-2-ones and Tetrahydro-3-aryl-1,3-oxazin-2-ones via the Iodocyclocarbamation Reaction: Access to Privileged Chemical Structures and Scope and Limitations of the Method.

Bell AC, Boomsma AB, Flikweert NE, Hohlman RM, Zhang S, Blankespoor RL, Biros SM, Staples RJ, Brickner SJ, Barbachyn MR. Bell AC, et al. Among authors: barbachyn mr. J Org Chem. 2020 May 15;85(10):6323-6337. doi: 10.1021/acs.joc.9b03400. Epub 2020 May 5. J Org Chem. 2020. PMID: 32316722

5

The oxazolidinones: past, present, and future.

Shaw KJ, Barbachyn MR. Shaw KJ, et al. Among authors: barbachyn mr. Ann N Y Acad Sci. 2011 Dec;1241:48-70. doi: 10.1111/j.1749-6632.2011.06330.x. Ann N Y Acad Sci. 2011. PMID: 22191526 Review.

6

5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV.

Starr JT, Sciotti RJ, Hanna DL, Huband MD, Mullins LM, Cai H, Gage JW, Lockard M, Rauckhorst MR, Owen RM, Lall MS, Tomilo M, Chen H, McCurdy SP, Barbachyn MR. Starr JT, et al. Among authors: barbachyn mr. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5302-6. doi: 10.1016/j.bmcl.2009.07.141. Epub 2009 Aug 3. Bioorg Med Chem Lett. 2009. PMID: 19683922

7

Synthesis of (-)-PNU-286607 by asymmetric cyclization of alkylidene barbiturates.

Ruble JC, Hurd AR, Johnson TA, Sherry DA, Barbachyn MR, Toogood PL, Bundy GL, Graber DR, Kamilar GM. Ruble JC, et al. Among authors: barbachyn mr. J Am Chem Soc. 2009 Mar 25;131(11):3991-7. doi: 10.1021/ja808014h. J Am Chem Soc. 2009. PMID: 19260642

8

Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.

Miller AA, Bundy GL, Mott JE, Skepner JE, Boyle TP, Harris DW, Hromockyj AE, Marotti KR, Zurenko GE, Munzner JB, Sweeney MT, Bammert GF, Hamel JC, Ford CW, Zhong WZ, Graber DR, Martin GE, Han F, Dolak LA, Seest EP, Ruble JC, Kamilar GM, Palmer JR, Banitt LS, Hurd AR, Barbachyn MR. Miller AA, et al. Among authors: barbachyn mr. Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12. doi: 10.1128/AAC.00247-08. Epub 2008 Jun 2. Antimicrob Agents Chemother. 2008. PMID: 18519725 Free PMC article.

9

Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections.

Brickner SJ, Barbachyn MR, Hutchinson DK, Manninen PR. Brickner SJ, et al. Among authors: barbachyn mr. J Med Chem. 2008 Apr 10;51(7):1981-90. doi: 10.1021/jm800038g. Epub 2008 Mar 14. J Med Chem. 2008. PMID: 18338841 Review. No abstract available.

10

Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.

Poel TJ, Thomas RC, Adams WJ, Aristoff PA, Barbachyn MR, Boyer FE, Brieland J, Brideau R, Brodfuehrer J, Brown AP, Choy AL, Dermyer M, Dority M, Ford CW, Gadwood RC, Hanna D, Hongliang C, Huband MD, Huber C, Kelly R, Kim JY, Martin JP Jr, Pagano PJ, Ross D, Skerlos L, Sulavik MC, Zhu T, Zurenko GE, Prasad JV. Poel TJ, et al. Among authors: barbachyn mr. J Med Chem. 2007 Nov 29;50(24):5886-9. doi: 10.1021/jm070708p. Epub 2007 Nov 8. J Med Chem. 2007. PMID: 17988109

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