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Assigning functionality to cysteines by base editing of cancer dependency genes.
Li H, Ma T, Remsberg JR, Won SJ, DeMeester KE, Njomen E, Ogasawara D, Zhao KT, Huang TP, Lu B, Simon GM, Melillo B, Schreiber SL, Lykke-Andersen J, Liu DR, Cravatt BF. Li H, et al. Among authors: schreiber sl. Nat Chem Biol. 2023 Nov;19(11):1320-1330. doi: 10.1038/s41589-023-01428-w. Epub 2023 Oct 2. Nat Chem Biol. 2023. PMID: 37783940 Free PMC article.
A small molecule that binds Hedgehog and blocks its signaling in human cells.
Stanton BZ, Peng LF, Maloof N, Nakai K, Wang X, Duffner JL, Taveras KM, Hyman JM, Lee SW, Koehler AN, Chen JK, Fox JL, Mandinova A, Schreiber SL. Stanton BZ, et al. Among authors: schreiber sl. Nat Chem Biol. 2009 Mar;5(3):154-6. doi: 10.1038/nchembio.142. Epub 2009 Jan 18. Nat Chem Biol. 2009. PMID: 19151731 Free PMC article.
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.
Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, Palmer M, Shamji AF, Wawer MJ, McManus O, Wu M, Zou B, Yu H, Golden JE, Schoenen FJ, Simeonov A, Jadhav A, Jackson MR, Pinkerton AB, Chung TD, Griffin PR, Cravatt BF, Hodder PS, Roush WR, Roberts E, Chung DH, Jonsson CB, Noah JW, Severson WE, Ananthan S, Edwards B, Oprea TI, Conn PJ, Hopkins CR, Wood MR, Stauffer SR, Emmitte KA; NIH Molecular Libraries Project Team. Schreiber SL, et al. Cell. 2015 Jun 4;161(6):1252-65. doi: 10.1016/j.cell.2015.05.023. Cell. 2015. PMID: 26046436 Free PMC article. Review.
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.
Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT. Wellington S, et al. Among authors: schreiber sl. Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3. Nat Chem Biol. 2017. PMID: 28671682 Free PMC article.
Modular, stereocontrolled Cβ-H/Cα-C activation of alkyl carboxylic acids.
Shang M, Feu KS, Vantourout JC, Barton LM, Osswald HL, Kato N, Gagaring K, McNamara CW, Chen G, Hu L, Ni S, Fernández-Canelas P, Chen M, Merchant RR, Qin T, Schreiber SL, Melillo B, Yu JQ, Baran PS. Shang M, et al. Among authors: schreiber sl. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):8721-8727. doi: 10.1073/pnas.1903048116. Epub 2019 Apr 17. Proc Natl Acad Sci U S A. 2019. PMID: 30996125 Free PMC article.
The landscape of cancer cell line metabolism.
Li H, Ning S, Ghandi M, Kryukov GV, Gopal S, Deik A, Souza A, Pierce K, Keskula P, Hernandez D, Ann J, Shkoza D, Apfel V, Zou Y, Vazquez F, Barretina J, Pagliarini RA, Galli GG, Root DE, Hahn WC, Tsherniak A, Giannakis M, Schreiber SL, Clish CB, Garraway LA, Sellers WR. Li H, et al. Among authors: schreiber sl. Nat Med. 2019 May;25(5):850-860. doi: 10.1038/s41591-019-0404-8. Epub 2019 May 8. Nat Med. 2019. PMID: 31068703 Free PMC article.
553 results