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XBP1 promotes NRASG12D pre-B acute lymphoblastic leukaemia through IL-7 receptor signalling and provides a therapeutic vulnerability for oncogenic RAS.
Salimi A, Schemionek-Reinders M, Huber M, Vieri M, Patterson JB, Alten J, Brümmendorf TH, Kharabi Masouleh B, Appelmann I. Salimi A, et al. Among authors: patterson jb. J Cell Mol Med. 2023 Nov;27(21):3363-3377. doi: 10.1111/jcmm.17904. Epub 2023 Sep 27. J Cell Mol Med. 2023. PMID: 37753803 Free PMC article.
Inhibition of IRE1α RNase activity sensitizes patient-derived acute myeloid leukaemia cells to proteasome inhibitors.
Creedican S, Robinson CM, Mnich K, Islam MN, Szegezdi E, Clifford R, Krawczyk J, Patterson JB, FitzGerald SP, Summers M, Richardson C, Martin K, Gorman AM, Samali A. Creedican S, et al. Among authors: patterson jb. J Cell Mol Med. 2022 Aug;26(16):4629-4633. doi: 10.1111/jcmm.17479. Epub 2022 Jul 13. J Cell Mol Med. 2022. PMID: 35822520 Free PMC article. No abstract available.
Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer.
Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Zhao N, et al. Among authors: patterson jb. J Clin Invest. 2018 Apr 2;128(4):1283-1299. doi: 10.1172/JCI95873. Epub 2018 Feb 26. J Clin Invest. 2018. PMID: 29480818 Free PMC article.
Dual IRE1 RNase functions dictate glioblastoma development.
Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, Patterson JB, Pluquet O, Hetz C, Quillien V, Chatziioannou A, Chevet E. Lhomond S, et al. Among authors: patterson jb. EMBO Mol Med. 2018 Mar;10(3):e7929. doi: 10.15252/emmm.201707929. EMBO Mol Med. 2018. PMID: 29311133 Free PMC article.
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling.
Sheng X, Nenseth HZ, Qu S, Kuzu OF, Frahnow T, Simon L, Greene S, Zeng Q, Fazli L, Rennie PS, Mills IG, Danielsen H, Theis F, Patterson JB, Jin Y, Saatcioglu F. Sheng X, et al. Among authors: patterson jb. Nat Commun. 2019 Jan 24;10(1):323. doi: 10.1038/s41467-018-08152-3. Nat Commun. 2019. PMID: 30679434 Free PMC article.
Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts.
Ghavami S, Yeganeh B, Zeki AA, Shojaei S, Kenyon NJ, Ott S, Samali A, Patterson J, Alizadeh J, Moghadam AR, Dixon IMC, Unruh H, Knight DA, Post M, Klonisch T, Halayko AJ. Ghavami S, et al. Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L493-L504. doi: 10.1152/ajplung.00372.2017. Epub 2017 Oct 26. Am J Physiol Lung Cell Mol Physiol. 2018. PMID: 29074489 Free PMC article.
69 results