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Transcriptomic profiling and immuno-histological characterization of synovial biopsies in juvenile idiopathic arthritis (JIA) suggest two broad categories, with significant overlap with rheumatoid arthritis (RA).
Triaille C, Tilman G, Baert CA, Sokolova T, Loriot A, Nzeusseu-Toukap A, Meric de Bellefon L, Galant C, Boulanger C, Fonseca JE, Bouzin C, Durez P, Lauwerys BR, Limaye N. Triaille C, et al. Among authors: lauwerys br. Arthritis Rheumatol. 2024 May 23. doi: 10.1002/art.42922. Online ahead of print. Arthritis Rheumatol. 2024. PMID: 38782587
Disease activity drives transcriptomic heterogeneity in early untreated rheumatoid synovitis.
Triaille C, Tilman G, Sokolova T, Loriot A, Marchandise J, De Montjoye S, Nzeusseu-Toukap A, Méric de Bellefon L, Bouzin C, Galant C, Durez P, Lauwerys BR, Limaye N. Triaille C, et al. Among authors: lauwerys br. Ann Rheum Dis. 2023 Dec;82(12):1538-1546. doi: 10.1136/ard-2023-224068. Epub 2023 Jul 28. Ann Rheum Dis. 2023. PMID: 37507201 Free PMC article.
Paired Rheumatoid Arthritis Synovial Biopsies From Small and Large Joints Show Similar Global Transcriptomic Patterns With Enrichment of Private Specificity TCRB and TCR Signaling Pathways.
Triaille C, Vansteenkiste L, Constant M, Ambroise J, Méric de Bellefon L, Nzeusseu Toukap A, Sokolova T, Galant C, Coulie P, Carrasco J, Durez P, Lauwerys BR. Triaille C, et al. Among authors: lauwerys br. Front Immunol. 2020 Nov 23;11:593083. doi: 10.3389/fimmu.2020.593083. eCollection 2020. Front Immunol. 2020. PMID: 33329580 Free PMC article.
Deep sequencing reveals a DAP1 regulatory haplotype that potentiates autoimmunity in systemic lupus erythematosus.
Raj P, Song R, Zhu H, Riediger L, Jun DJ, Liang C, Arana C, Zhang B, Gao Y, Wakeland BE, Dozmorov I, Zhou J, Kelly JA, Lauwerys BR, Guthridge JM, Olsen NJ, Nath SK, Pasare C, van Oers N, Gilkeson G, Tsao BP, Gaffney PM, Gregersen PK, James JA, Zuo X, Karp DR, Li QZ, Wakeland EK. Raj P, et al. Among authors: lauwerys br. Genome Biol. 2020 Nov 19;21(1):281. doi: 10.1186/s13059-020-02184-z. Genome Biol. 2020. PMID: 33213505 Free PMC article.
Tapering of biological antirheumatic drugs in rheumatoid arthritis patients is achievable and cost-effective in daily clinical practice: data from the Brussels UCLouvain RA Cohort.
Dierckx S, Sokolova T, Lauwerys BR, Avramovska A, de Bellefon LM, Toukap AN, Stoenoiu M, Houssiau FA, Durez P. Dierckx S, et al. Among authors: lauwerys br. Arthritis Res Ther. 2020 Apr 28;22(1):96. doi: 10.1186/s13075-020-02165-4. Arthritis Res Ther. 2020. PMID: 32345367 Free PMC article.
Toll-like receptor 3 increases antigen-presenting cell responses to a pro-apoptotic stimulus, yet does not contribute to systemic lupus erythematosus genetic susceptibility.
De Groof A, Ducreux J, Vidal-Bralo L, Tyteca D, Galant C, Marot L, Coulie PG, Van den Eynde BJ, Rodriguez-Martinez L, Santos MJ, Suarez A, Carreira P, Marchini M, Gonzàlez A, Houssiau FA, Lauwerys BR. De Groof A, et al. Among authors: lauwerys br. Clin Exp Rheumatol. 2020 Sep-Oct;38(5):881-890. Epub 2020 Jan 20. Clin Exp Rheumatol. 2020. PMID: 31969218 Free article.
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