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Structural Insights into Partial Activation of the Prototypic G Protein-Coupled Adenosine A2A Receptor.
ACS Pharmacol Transl Sci. 2024 Apr 29;7(5):1415-1425. doi: 10.1021/acsptsci.4c00051. eCollection 2024 May 10.
ACS Pharmacol Transl Sci. 2024.
PMID: 38751633
Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.
Lopez V, Schuh HJM, Mirza S, Vaaßen VJ, Schmidt MS, Sylvester K, Idris RM, Renn C, Schäkel L, Pelletier J, Sévigny J, Naggi A, Scheffler B, Lee SY, Bendas G, Müller CE.
Lopez V, et al. Among authors: vaassen vj.
Front Immunol. 2023 Aug 29;14:1173634. doi: 10.3389/fimmu.2023.1173634. eCollection 2023.
Front Immunol. 2023.
PMID: 37711611
Free PMC article.
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Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction.
Claff T, Schlegel JG, Voss JH, Vaaßen VJ, Weiße RH, Cheng RKY, Markovic-Mueller S, Bucher D, Sträter N, Müller CE.
Claff T, et al. Among authors: vaassen vj.
Commun Chem. 2023 Jun 1;6(1):106. doi: 10.1038/s42004-023-00894-6.
Commun Chem. 2023.
PMID: 37264098
Free PMC article.
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Irreversible Antagonists for the Adenosine A2B Receptor.
Temirak A, Schlegel JG, Voss JH, Vaaßen VJ, Vielmuth C, Claff T, Müller CE.
Temirak A, et al. Among authors: vaassen vj.
Molecules. 2022 Jun 13;27(12):3792. doi: 10.3390/molecules27123792.
Molecules. 2022.
PMID: 35744918
Free PMC article.
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Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates.
Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaaßen VJ, Schlegel JG, Vielmuth C, Voß JH, Labahn J, Müller CE.
Claff T, et al. Among authors: vaassen vj.
Angew Chem Int Ed Engl. 2022 May 23;61(22):e202115545. doi: 10.1002/anie.202115545. Epub 2022 Mar 24.
Angew Chem Int Ed Engl. 2022.
PMID: 35174942
Free PMC article.
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