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Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.
Lopez V, Schuh HJM, Mirza S, Vaaßen VJ, Schmidt MS, Sylvester K, Idris RM, Renn C, Schäkel L, Pelletier J, Sévigny J, Naggi A, Scheffler B, Lee SY, Bendas G, Müller CE. Lopez V, et al. Among authors: vaassen vj. Front Immunol. 2023 Aug 29;14:1173634. doi: 10.3389/fimmu.2023.1173634. eCollection 2023. Front Immunol. 2023. PMID: 37711611 Free PMC article.
Irreversible Antagonists for the Adenosine A2B Receptor.
Temirak A, Schlegel JG, Voss JH, Vaaßen VJ, Vielmuth C, Claff T, Müller CE. Temirak A, et al. Among authors: vaassen vj. Molecules. 2022 Jun 13;27(12):3792. doi: 10.3390/molecules27123792. Molecules. 2022. PMID: 35744918 Free PMC article.
Single Stabilizing Point Mutation Enables High-Resolution Co-Crystal Structures of the Adenosine A2A Receptor with Preladenant Conjugates.
Claff T, Klapschinski TA, Tiruttani Subhramanyam UK, Vaaßen VJ, Schlegel JG, Vielmuth C, Voß JH, Labahn J, Müller CE. Claff T, et al. Among authors: vaassen vj. Angew Chem Int Ed Engl. 2022 May 23;61(22):e202115545. doi: 10.1002/anie.202115545. Epub 2022 Mar 24. Angew Chem Int Ed Engl. 2022. PMID: 35174942 Free PMC article.