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Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.
Lopez V, Schuh HJM, Mirza S, Vaaßen VJ, Schmidt MS, Sylvester K, Idris RM, Renn C, Schäkel L, Pelletier J, Sévigny J, Naggi A, Scheffler B, Lee SY, Bendas G, Müller CE. Lopez V, et al. Among authors: schakel l. Front Immunol. 2023 Aug 29;14:1173634. doi: 10.3389/fimmu.2023.1173634. eCollection 2023. Front Immunol. 2023. PMID: 37711611 Free PMC article.
Fluorescent Probes for Ecto-5'-nucleotidase (CD73).
Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schäkel L, Al-Hroub H, Wang Y, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Müller CE. Schmies CC, et al. Among authors: schakel l. ACS Med Chem Lett. 2020 Sep 3;11(11):2253-2260. doi: 10.1021/acsmedchemlett.0c00391. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33214837 Free PMC article.
Targeting the Main Protease of SARS-CoV-2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors.
Breidenbach J, Lemke C, Pillaiyar T, Schäkel L, Al Hamwi G, Diett M, Gedschold R, Geiger N, Lopez V, Mirza S, Namasivayam V, Schiedel AC, Sylvester K, Thimm D, Vielmuth C, Phuong Vu L, Zyulina M, Bodem J, Gütschow M, Müller CE. Breidenbach J, et al. Among authors: schakel l. Angew Chem Int Ed Engl. 2021 Apr 26;60(18):10423-10429. doi: 10.1002/anie.202016961. Epub 2021 Mar 24. Angew Chem Int Ed Engl. 2021. PMID: 33655614 Free PMC article.
Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity.
Gao S, Sylvester K, Song L, Claff T, Jing L, Woodson M, Weiße RH, Cheng Y, Schäkel L, Petry M, Gütschow M, Schiedel AC, Sträter N, Kang D, Xu S, Toth K, Tavis J, Tollefson AE, Müller CE, Liu X, Zhan P. Gao S, et al. Among authors: schakel l. J Med Chem. 2022 Oct 13;65(19):13343-13364. doi: 10.1021/acs.jmedchem.2c01146. Epub 2022 Sep 15. J Med Chem. 2022. PMID: 36107752
24 results