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Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) - a promising target for the immunotherapy of cancer.
Front Immunol. 2023 Aug 29;14:1173634. doi: 10.3389/fimmu.2023.1173634. eCollection 2023.
Front Immunol. 2023.
PMID: 37711611
Free PMC article.
Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 - a promising target for cancer immunotherapy.
Schäkel L, Mirza S, Winzer R, Lopez V, Idris R, Al-Hroub H, Pelletier J, Sévigny J, Tolosa E, Müller CE.
Schäkel L, et al.
J Immunother Cancer. 2022 Aug;10(8):e004660. doi: 10.1136/jitc-2022-004660.
J Immunother Cancer. 2022.
PMID: 35981785
Free PMC article.
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Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors.
Schäkel L, Schmies CC, Idris RM, Luo X, Lee SY, Lopez V, Mirza S, Vu TH, Pelletier J, Sévigny J, Namasivayam V, Müller CE.
Schäkel L, et al. Among authors: idris rm.
Front Pharmacol. 2020 Sep 8;11:1294. doi: 10.3389/fphar.2020.01294. eCollection 2020.
Front Pharmacol. 2020.
PMID: 33013365
Free PMC article.
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Fluorescent Probes for Ecto-5'-nucleotidase (CD73).
Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schäkel L, Al-Hroub H, Wang Y, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Müller CE.
Schmies CC, et al. Among authors: idris rm.
ACS Med Chem Lett. 2020 Sep 3;11(11):2253-2260. doi: 10.1021/acsmedchemlett.0c00391. eCollection 2020 Nov 12.
ACS Med Chem Lett. 2020.
PMID: 33214837
Free PMC article.
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2-Substituted α,β-Methylene-ADP Derivatives: Potent Competitive Ecto-5'-nucleotidase (CD73) Inhibitors with Variable Binding Modes.
Bhattarai S, Pippel J, Scaletti E, Idris R, Freundlieb M, Rolshoven G, Renn C, Lee SY, Abdelrahman A, Zimmermann H, El-Tayeb A, Müller CE, Sträter N.
Bhattarai S, et al.
J Med Chem. 2020 Mar 26;63(6):2941-2957. doi: 10.1021/acs.jmedchem.9b01611. Epub 2020 Feb 28.
J Med Chem. 2020.
PMID: 32045236
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Structure-Activity Relationship of 3-Methylcytidine-5'-α,β-methylenediphosphates as CD73 Inhibitors.
Scortichini M, Idris RM, Moschütz S, Keim A, Salmaso V, Dobelmann C, Oliva P, Losenkova K, Irjala H, Vaittinen S, Sandholm J, Yegutkin GG, Sträter N, Junker A, Müller CE, Jacobson KA.
Scortichini M, et al. Among authors: idris rm.
J Med Chem. 2022 Feb 10;65(3):2409-2433. doi: 10.1021/acs.jmedchem.1c01852. Epub 2022 Jan 26.
J Med Chem. 2022.
PMID: 35080883
Free PMC article.
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