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PLK1 inhibition dampens NLRP3 inflammasome-elicited response in inflammatory disease models.
Baldrighi M, Doreth C, Li Y, Zhao X, Warner E, Chenoweth H, Kishore K, Umrania Y, Minde DP, Thome S, Yu X, Lu Y, Knapton A, Harrison J, Clarke M, Latz E, de Cárcer G, Malumbres M, Ryffel B, Bryant C, Liu J, Lilley KS, Mallat Z, Li X. Baldrighi M, et al. Among authors: latz e. J Clin Invest. 2023 Nov 1;133(21):e162129. doi: 10.1172/JCI162129. J Clin Invest. 2023. PMID: 37698938 Free PMC article.
NLRP3 inflammasomes link inflammation and metabolic disease.
De Nardo D, Latz E. De Nardo D, et al. Among authors: latz e. Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4. Trends Immunol. 2011. PMID: 21733753 Free PMC article. Review.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA. Coll RC, et al. Among authors: latz e. Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16. Nat Med. 2015. PMID: 25686105 Free PMC article.
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation.
Primiano MJ, Lefker BA, Bowman MR, Bree AG, Hubeau C, Bonin PD, Mangan M, Dower K, Monks BG, Cushing L, Wang S, Guzova J, Jiao A, Lin LL, Latz E, Hepworth D, Hall JP. Primiano MJ, et al. Among authors: latz e. J Immunol. 2016 Sep 15;197(6):2421-33. doi: 10.4049/jimmunol.1600035. Epub 2016 Aug 12. J Immunol. 2016. PMID: 27521339
Activation of the NLRP3 inflammasome in microglia: the role of ceramide.
Scheiblich H, Schlütter A, Golenbock DT, Latz E, Martinez-Martinez P, Heneka MT. Scheiblich H, et al. Among authors: latz e. J Neurochem. 2017 Dec;143(5):534-550. doi: 10.1111/jnc.14225. Epub 2017 Oct 26. J Neurochem. 2017. PMID: 28940479 Free article.
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming.
Christ A, Günther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baßler K, Klee K, Schulte-Schrepping J, Ulas T, Moorlag SJCFM, Kumar V, Park MH, Joosten LAB, Groh LA, Riksen NP, Espevik T, Schlitzer A, Li Y, Fitzgerald ML, Netea MG, Schultze JL, Latz E. Christ A, et al. Among authors: latz e. Cell. 2018 Jan 11;172(1-2):162-175.e14. doi: 10.1016/j.cell.2017.12.013. Cell. 2018. PMID: 29328911 Free PMC article.
Targeting the NLRP3 inflammasome in inflammatory diseases.
Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Mangan MSJ, et al. Among authors: latz e. Nat Rev Drug Discov. 2018 Aug;17(8):588-606. doi: 10.1038/nrd.2018.97. Epub 2018 Jul 20. Nat Rev Drug Discov. 2018. PMID: 30026524 Review.
330 results