Kakinuma H - Search Results

1

Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor.

Imai Y, Suzuki R, Wakasugi D, Matsuda D, Tanaka-Yamamoto N, Ohki Y, Mima M, Endo M, Tabata R, Matsuzawa H, Hasegawa Y, Kato S, Sugisaki M, Miyagawa H, Fujimoto N, Fukunaga T, Kato S, Takahashi T, Kakinuma H. Imai Y, et al. Among authors: kakinuma h. Bioorg Med Chem. 2023 Oct 1;93:117460. doi: 10.1016/j.bmc.2023.117460. Epub 2023 Aug 26. Bioorg Med Chem. 2023. PMID: 37660465

2

The preparation and crystallization of Fab fragments of a family of mouse esterolytic catalytic antibodies and their complexes with a transition-state analogue.

Muranova TA, Ruzheinikov SN, Sedelnikova SE, Moir A, Partridge LJ, Kakinuma H, Takahashi N, Shimazaki K, Sun J, Nishi Y, Rice DW. Muranova TA, et al. Among authors: kakinuma h. Acta Crystallogr D Biol Crystallogr. 2001 Aug;57(Pt 8):1192-5. doi: 10.1107/s0907444901010149. Epub 2001 Jul 23. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11468416

3

Directed evolution governed by controlling the molecular recognition between an abzyme and its haptenic transition-state analog.

Takahashi-Ando N, Kakinuma H, Fujii I, Nishi Y. Takahashi-Ando N, et al. Among authors: kakinuma h. J Immunol Methods. 2004 Nov;294(1-2):1-14. doi: 10.1016/j.jim.2004.06.018. J Immunol Methods. 2004. PMID: 15604011

4

Pyrazole and isoxazole derivatives as new, potent, and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

Nakamura T, Sato M, Kakinuma H, Miyata N, Taniguchi K, Bando K, Koda A, Kameo K. Nakamura T, et al. Among authors: kakinuma h. J Med Chem. 2003 Dec 4;46(25):5416-27. doi: 10.1021/jm020557k. J Med Chem. 2003. PMID: 14640550

5

Imidazole derivatives as new potent and selective 20-HETE synthase inhibitors.

Nakamura T, Kakinuma H, Umemiya H, Amada H, Miyata N, Taniguchi K, Bando K, Sato M. Nakamura T, et al. Among authors: kakinuma h. Bioorg Med Chem Lett. 2004 Jan 19;14(2):333-6. doi: 10.1016/j.bmcl.2003.11.005. Bioorg Med Chem Lett. 2004. PMID: 14698153

6

Pyrazole derivatives as new potent and selective 20-hydroxy-5,8,11,14-eicosatetraenoic acid synthase inhibitors.

Nakamura T, Kakinuma H, Amada H, Miyata N, Taniguchi K, Koda A, Sato M. Nakamura T, et al. Among authors: kakinuma h. Bioorg Med Chem. 2004 Dec 1;12(23):6209-19. doi: 10.1016/j.bmc.2004.08.047. Bioorg Med Chem. 2004. PMID: 15519164

7

Structure-activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor.

Nozawa D, Okubo T, Ishii T, Kakinuma H, Chaki S, Okuyama S, Nakazato A. Nozawa D, et al. Among authors: kakinuma h. Bioorg Med Chem. 2007 Mar 1;15(5):1989-2005. doi: 10.1016/j.bmc.2006.12.039. Epub 2006 Dec 30. Bioorg Med Chem. 2007. PMID: 17234422

8

(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.

Kakinuma H, Oi T, Hashimoto-Tsuchiya Y, Arai M, Kawakita Y, Fukasawa Y, Iida I, Hagima N, Takeuchi H, Chino Y, Asami J, Okumura-Kitajima L, Io F, Yamamoto D, Miyata N, Takahashi T, Uchida S, Yamamoto K. Kakinuma H, et al. J Med Chem. 2010 Apr 22;53(8):3247-61. doi: 10.1021/jm901893x. J Med Chem. 2010. PMID: 20302302

9

Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists.

Matsuda D, Kobashi Y, Mikami A, Kawamura M, Shiozawa F, Kawabe K, Hamada M, Oda K, Nishimoto S, Kimura K, Miyoshi M, Takayama N, Kakinuma H, Ohtake N. Matsuda D, et al. Among authors: kakinuma h. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3441-6. doi: 10.1016/j.bmcl.2016.06.050. Epub 2016 Jun 20. Bioorg Med Chem Lett. 2016. PMID: 27390068

10

Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships.

Matsuda D, Kobashi Y, Mikami A, Kawamura M, Shiozawa F, Kawabe K, Hamada M, Nishimoto S, Kimura K, Miyoshi M, Takayama N, Kakinuma H, Ohtake N. Matsuda D, et al. Among authors: kakinuma h. Bioorg Med Chem. 2017 Aug 15;25(16):4339-4354. doi: 10.1016/j.bmc.2017.06.014. Epub 2017 Jun 13. Bioorg Med Chem. 2017. PMID: 28662959

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