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Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains.
de Araújo ACJ, Freitas PR, Araújo IM, Siqueira GM, de Oliveira Borges JA, Alves DS, Miranda GM, Dos Santos Nascimento IJ, de Araújo-Júnior JX, da Silva-Júnior EF, de Aquino TM, Junior FJBM, Marinho ES, Dos Santos HS, Tintino SR, Coutinho HDM. de Araújo ACJ, et al. Among authors: dos santos hs. Fundam Clin Pharmacol. 2024 Feb;38(1):84-98. doi: 10.1111/fcp.12950. Epub 2023 Aug 30. Fundam Clin Pharmacol. 2024. PMID: 37649138
Antimicrobial activity of the lupane triterpene 3β,6β,16β-trihydroxylup-20(29)-ene isolated from Combretum leprosum Mart.
Cruz BG, Rodrigues Teixeira AM, Silva PTD, Vasconcelos Evaristo FF, de Vaconcelos MA, Holanda Teixeira E, Dos Santos HS, Bandeira PN, Sena-Júnior DM, Barreto VP, Coutinho HDM. Cruz BG, et al. Among authors: dos santos hs. J Med Microbiol. 2019 Oct;68(10):1438-1444. doi: 10.1099/jmm.0.001056. Epub 2019 Aug 6. J Med Microbiol. 2019. PMID: 31385784
Evaluation of antibacterial and enhancement of antibiotic action by the flavonoid kaempferol 7-O-β-D-(6″-O-cumaroyl)-glucopyranoside isolated from Croton piauhiensis müll.
Cruz BG, Dos Santos HS, Bandeira PN, Rodrigues THS, Matos MGC, Nascimento MF, de Carvalho GGC, Braz-Filho R, Teixeira AMR, Tintino SR, Coutinho HDM. Cruz BG, et al. Among authors: dos santos hs. Microb Pathog. 2020 Jun;143:104144. doi: 10.1016/j.micpath.2020.104144. Epub 2020 Mar 17. Microb Pathog. 2020. PMID: 32194182
Chemical composition and potentiating action of Norfloxacin mediated by the essential oil of Piper caldense C.D.C. against Staphylococcus aureus strains overexpressing efflux pump genes.
Leal ALAB, Bezerra CF, Confortin C, da Silva LE, Marinho EM, Marinho MM, Vasconcelos MA, da Silva TG, Marinho ES, Teixeira AMR, Coutinho HDM, Barreto HM, Dos Santos HS. Leal ALAB, et al. Among authors: dos santos hs. Arch Microbiol. 2021 Sep;203(7):4727-4736. doi: 10.1007/s00203-021-02393-5. Epub 2021 May 29. Arch Microbiol. 2021. PMID: 34052872 Free PMC article.
Antibacterial and antibiotic modifying activity, ADMET study and molecular docking of synthetic chalcone (E)-1-(2-hydroxyphenyl)-3-(2,4-dimethoxy-3-methylphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying NorA and MepA efflux pumps.
Rocha JE, de Freitas TS, da Cunha Xavier J, Pereira RLS, Junior FNP, Nogueira CES, Marinho MM, Bandeira PN, de Oliveira MR, Marinho ES, Teixeira AMR, Dos Santos HS, Coutinho HDM. Rocha JE, et al. Among authors: dos santos hs. Biomed Pharmacother. 2021 Aug;140:111768. doi: 10.1016/j.biopha.2021.111768. Epub 2021 May 28. Biomed Pharmacother. 2021. PMID: 34058442 Free article.
Synthesis, antibiotic modifying activity, ADMET study and molecular docking of chalcone (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying MepA efflux pumps.
Rocha JE, de Freitas TS, da Cunha Xavier J, Pereira RLS, Pereira FN Jr, Nogueira CES, Marinho MM, Bandeira PN, Fernandes MAA, Marinho ES, Teixeira AMR, Dos Santos HS, Coutinho HDM. Rocha JE, et al. Among authors: dos santos hs. Arch Microbiol. 2021 Dec 23;204(1):63. doi: 10.1007/s00203-021-02666-z. Arch Microbiol. 2021. PMID: 34940944
Hypoglycemic effect on adult zebrafish (Danio rerio) of the 3β-6β-16β-trihydroxylup-20(29)-ene triterpene isolated from Combretum leprosum leaves in vivo and in silico approach.
Coutinho MR, da Silva AW, Ferreira MKA, de Lima Rebouças E, Mendes FRS, Teixeira EH, Marinho EM, Marinho MM, Marinho ES, Teixeira AMR, de Menezes JESA, Dos Santos HS. Coutinho MR, et al. Among authors: dos santos hs. Fundam Clin Pharmacol. 2022 Oct;36(5):818-826. doi: 10.1111/fcp.12776. Epub 2022 Mar 14. Fundam Clin Pharmacol. 2022. PMID: 35261066
Potentiation of antibiotic activity, and efflux pumps inhibition by (2E)-1-(4-aminophenyl)-3-(4-fluorophenyl)prop-2-en-1-one.
Hemília de Souza Nunes P, Sampaio de Freitas T, Esmeraldo Rocha J, Luiz Silva Pereira R, Machado Marinho M, de Oliveira MR, Santos Oliveira L, Machado Marinho E, Silva Marinho E, Sousa Aquino S, Emidio Sampaio Nogueira C, Douglas Melo Coutinho H, Nogueira Bandeira P, Magno Rodrigues Teixeira A, Dos Santos HS. Hemília de Souza Nunes P, et al. Among authors: santos oliveira l, dos santos hs. Fundam Clin Pharmacol. 2022 Dec;36(6):1066-1082. doi: 10.1111/fcp.12785. Epub 2022 May 19. Fundam Clin Pharmacol. 2022. PMID: 35475507
ADMET study, spectroscopic characterization and effect of synthetic nitro chalcone in combination with norfloxacin, ciprofloxacin, and ethidium bromide against Staphylococcus aureus efflux pumps.
Rocha JE, de Freitas TS, Xavier JC, Pereira RLS, Pereira Junior FN, Nogueira CES, Marinho MM, Bandeira PN, Rodrigues LG, Marinho ES, de Lacerda BCGV, de Andrade EM, Teixeira AMR, Dos Santos HS, Coutinho HDM. Rocha JE, et al. Among authors: dos santos hs. Fundam Clin Pharmacol. 2023 Feb;37(1):163-173. doi: 10.1111/fcp.12830. Epub 2022 Sep 16. Fundam Clin Pharmacol. 2023. PMID: 36082507
82 results