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Sequence Analysis of Inducible, Replication-Competent Virus Reveals No Evidence of HIV-1 Evolution During Suppressive Antiviral Therapy, Indicating a Lack of Ongoing Viral Replication.
Lee SK, Sondgeroth A, Xu Y, Warren J, Zhou S, Gilleece M, Hauser BM, Gay CL, Kuruc JD, Archin NM, Eron JJ, Margolis DM, Goonetilleke N, Swanstrom R. Lee SK, et al. Among authors: archin nm. Open Forum Infect Dis. 2024 Apr 17;11(5):ofae212. doi: 10.1093/ofid/ofae212. eCollection 2024 May. Open Forum Infect Dis. 2024. PMID: 38756763 Free PMC article.
The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus.
Joseph SB, Abrahams MR, Moeser M, Tyers L, Archin NM, Council OD, Sondgeroth A, Spielvogel E, Emery A, Zhou S, Doolabh D, Ismail SD, Karim SA, Margolis DM, Pond SK, Garrett N, Swanstrom R, Williamson C. Joseph SB, et al. Among authors: archin nm. PLoS Pathog. 2024 Feb 29;20(2):e1011974. doi: 10.1371/journal.ppat.1011974. eCollection 2024 Feb. PLoS Pathog. 2024. PMID: 38422171 Free PMC article.
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobarrubias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL; MACS/WIHS combined cohort study (MWCSS). Shahid A, et al. Among authors: archin nm. J Virol. 2024 Feb 20;98(2):e0165523. doi: 10.1128/jvi.01655-23. Epub 2024 Jan 12. J Virol. 2024. PMID: 38214547 Free PMC article.
Dominant CD4+ T cell receptors remain stable throughout antiretroviral therapy-mediated immune restoration in people with HIV.
Sponaugle A, Weideman AMK, Ranek J, Atassi G, Kuruc J, Adimora AA, Archin NM, Gay C, Kuritzkes DR, Margolis DM, Vincent BG, Stanley N, Hudgens MG, Eron JJ, Goonetilleke N. Sponaugle A, et al. Among authors: archin nm. Cell Rep Med. 2023 Nov 21;4(11):101268. doi: 10.1016/j.xcrm.2023.101268. Epub 2023 Nov 9. Cell Rep Med. 2023. PMID: 37949070 Free PMC article.
A truncated HIV Tat demonstrates potent and specific latency reversal activity.
Van Gulck E, Pardons M, Nijs E, Verheyen N, Dockx K, Van Den Eynde C, Battivelli E, Vega J, Florence E, Autran B, Archin NM, Margolis DM, Katlama C, Hamimi C, Van Den Wyngaert I, Eyassu F, Vandekerckhove L, Boden D. Van Gulck E, et al. Among authors: archin nm. Antimicrob Agents Chemother. 2023 Nov 15;67(11):e0041723. doi: 10.1128/aac.00417-23. Epub 2023 Oct 24. Antimicrob Agents Chemother. 2023. PMID: 37874295 Free PMC article.
HIVepsilon-seq-scalable characterization of intact persistent proviral HIV reservoirs in women.
Barton K, Ferguson JM, Deveson IW, Falcinelli SD, James KS, Kirchherr J, Ramirez C, Gay CL, Hammond JM, Bevear B, Carswell SL, Margolis DM, Smith MA, Adimora AA, Archin NM. Barton K, et al. Among authors: archin nm. J Virol. 2023 Nov 30;97(11):e0070523. doi: 10.1128/jvi.00705-23. Epub 2023 Oct 16. J Virol. 2023. PMID: 37843370 Free PMC article.
AZD5582 plus SIV-specific antibodies reduce lymph node viral reservoirs in antiretroviral therapy-suppressed macaques.
Dashti A, Sukkestad S, Horner AM, Neja M, Siddiqi Z, Waller C, Goldy J, Monroe D, Lin A, Schoof N, Singh V, Mavigner M, Lifson JD, Deleage C, Tuyishime M, Falcinelli SD, King HAD, Ke R, Mason RD, Archin NM, Dunham RM, Safrit JT, Jean S, Perelson AS, Margolis DM, Ferrari G, Roederer M, Silvestri G, Chahroudi A. Dashti A, et al. Among authors: archin nm. Nat Med. 2023 Oct;29(10):2535-2546. doi: 10.1038/s41591-023-02570-7. Epub 2023 Oct 2. Nat Med. 2023. PMID: 37783968 Free PMC article.
The replication-competent HIV reservoir is a genetically restricted, younger subset of the overall pool of HIV proviruses persisting during therapy, which is highly genetically stable over time.
Shahid A, MacLennan S, Jones BR, Sudderuddin H, Dang Z, Cobamibias K, Duncan MC, Kinloch NN, Dapp MJ, Archin NM, Fischl MA, Ofotokun I, Adimora A, Gange S, Aouizerat B, Kuniholm MH, Kassaye S, Mullins JI, Goldstein H, Joy JB, Anastos K, Brumme ZL. Shahid A, et al. Among authors: archin nm. Res Sq [Preprint]. 2023 Aug 16:rs.3.rs-3259040. doi: 10.21203/rs.3.rs-3259040/v1. Res Sq. 2023. PMID: 37645749 Free PMC article. Updated. Preprint.
78 results