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An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics.
Bern M, Nilsen J, Ferrarese M, Sand KMK, Gjølberg TT, Lode HE, Davidson RJ, Camire RM, Bækkevold ES, Foss S, Grevys A, Dalhus B, Wilson J, Høydahl LS, Christianson GJ, Roopenian DC, Schlothauer T, Michaelsen TE, Moe MC, Lombardi S, Pinotti M, Sandlie I, Branchini A, Andersen JT. Bern M, et al. Among authors: roopenian dc. Sci Transl Med. 2020 Oct 14;12(565):eabb0580. doi: 10.1126/scitranslmed.abb0580. Sci Transl Med. 2020. PMID: 33055243
An intact C-terminal end of albumin is required for its long half-life in humans.
Nilsen J, Trabjerg E, Grevys A, Azevedo C, Brennan SO, Stensland M, Wilson J, Sand KMK, Bern M, Dalhus B, Roopenian DC, Sandlie I, Rand KD, Andersen JT. Nilsen J, et al. Among authors: roopenian dc. Commun Biol. 2020 Apr 20;3(1):181. doi: 10.1038/s42003-020-0903-7. Commun Biol. 2020. PMID: 32313072 Free PMC article.
169 results