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The ERK inhibitor LY3214996 augments anti-PD-1 immunotherapy in preclinical mouse models of BRAFV600E melanoma brain metastasis.
Neuro Oncol. 2024 May 3;26(5):889-901. doi: 10.1093/neuonc/noad248.
Neuro Oncol. 2024.
PMID: 38134951
CDK4/6 Inhibition Sensitizes Intracranial Tumors to PD-1 Blockade in Preclinical Models of Brain Metastasis.
Nayyar N, de Sauvage MA, Chuprin J, Sullivan EM, Singh M, Torrini C, Zhang BS, Bandyopadhyay S, Daniels KA, Alvarez-Breckenridge C, Dahal A, Brehm MA, Brastianos PK.
Nayyar N, et al. Among authors: de sauvage ma.
Clin Cancer Res. 2024 Jan 17;30(2):420-435. doi: 10.1158/1078-0432.CCR-23-0433.
Clin Cancer Res. 2024.
PMID: 37611074
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Leveraging translational insights toward precision medicine approaches for brain metastases.
Kim AE, Nieblas-Bedolla E, de Sauvage MA, Brastianos PK.
Kim AE, et al. Among authors: de sauvage ma.
Nat Cancer. 2023 Jul;4(7):955-967. doi: 10.1038/s43018-023-00585-0. Epub 2023 Jul 24.
Nat Cancer. 2023.
PMID: 37491527
Free PMC article.
Review.
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Pembrolizumab in brain metastases of diverse histologies: phase 2 trial results.
Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Lin NU, Overmoyer B, Wen PY, Nayak L, Cohen JV, Dietrich J, Eichler A, Heist RS, Krop I, Lawrence D, Ligibel J, Tolaney S, Mayer E, Winer E, Bent B, de Sauvage MA, Ijad N, Larson JM, Marion B, Nason S, Murthy N, Ratcliff S, Summers EJ, Mahar M, Shih HA, Oh K, Cahill DP, Gerstner ER, Sullivan RJ.
Brastianos PK, et al. Among authors: de sauvage ma.
Nat Med. 2023 Jul;29(7):1728-1737. doi: 10.1038/s41591-023-02392-7. Epub 2023 Jun 2.
Nat Med. 2023.
PMID: 37268724
Free PMC article.
Clinical Trial.
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Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas.
Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, Chukwueke U, Forst DA, Arrillaga-Romany IC, Dietrich J, Corbin Z, Moliterno J, Baehring J, White M, Lou KW, Larson J, de Sauvage MA, Evancic K, Mora J, Nayyar N, Loeffler J, Oh K, Shih HA, Curry WT, Cahill DP, Barker FG, Gerstner ER, Santagata S.
Brastianos PK, et al. Among authors: de sauvage ma.
Nat Commun. 2022 Mar 14;13(1):1325. doi: 10.1038/s41467-022-29052-7.
Nat Commun. 2022.
PMID: 35289329
Free PMC article.
Clinical Trial.
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