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Randomized placebo-controlled crossover study to assess tolerability and pharmacodynamics of zagociguat, a soluble guanylyl cyclase stimulator, in healthy elderly.
van Kraaij SJW, Borghans L, Klaassen ES, Gal P, van der Grond J, Tripp K, Winrow C, Glasser C, Groeneveld GJ. van Kraaij SJW, et al. Among authors: gal p. Br J Clin Pharmacol. 2023 Dec;89(12):3606-3617. doi: 10.1111/bcp.15861. Epub 2023 Aug 13. Br J Clin Pharmacol. 2023. PMID: 37488930 Clinical Trial.
Challenging the challenge: A randomized controlled trial evaluating the inflammatory response and pain perception of healthy volunteers after single-dose LPS administration, as a potential model for inflammatory pain in early-phase drug development.
Hijma HJ, Moss LM, Gal P, Ziagkos D, de Kam ML, Moerland M, Groeneveld GJ. Hijma HJ, et al. Among authors: gal p. Brain Behav Immun. 2020 Aug;88:515-528. doi: 10.1016/j.bbi.2020.04.033. Epub 2020 Apr 16. Brain Behav Immun. 2020. PMID: 32305572 Free article. Clinical Trial.
A randomized controlled trial with a delayed-type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man.
Saghari M, Gal P, Ziagkos D, Burggraaf J, Powell JF, Brennan N, Rissmann R, van Doorn MBA, Moerland M. Saghari M, et al. Among authors: gal p. Br J Clin Pharmacol. 2021 Apr;87(4):1953-1962. doi: 10.1111/bcp.14588. Epub 2020 Oct 28. Br J Clin Pharmacol. 2021. PMID: 33025648 Free PMC article. Clinical Trial.
OX40L Inhibition Suppresses KLH-driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof-of-Pharmacology for KY1005.
Saghari M, Gal P, Gilbert S, Yateman M, Porter-Brown B, Brennan N, Quaratino S, Wilson R, Grievink HW, Klaassen ES, Bergmann KR, Burggraaf J, van Doorn MBA, Powell J, Moerland M, Rissmann R. Saghari M, et al. Among authors: gal p. Clin Pharmacol Ther. 2022 May;111(5):1121-1132. doi: 10.1002/cpt.2539. Epub 2022 Mar 1. Clin Pharmacol Ther. 2022. PMID: 35092305 Free PMC article. Clinical Trial.
Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers.
Saghari M, Gal P, Grievink HW, Klaassen ES, Itano A, McHale D, Moerland M. Saghari M, et al. Among authors: gal p. Front Immunol. 2022 Dec 7;13:1009304. doi: 10.3389/fimmu.2022.1009304. eCollection 2022. Front Immunol. 2022. PMID: 36582231 Free PMC article. Clinical Trial.
467 results