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An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion.
Noordstra I, Hermoso MD, Schimmel L, Bonfim-Melo A, Currin-Ross D, Duong CN, Kalappurakkal JM, Morris RG, Vestweber D, Mayor S, Gordon E, Roca-Cusachs P, Yap AS. Noordstra I, et al. Among authors: schimmel l. Dev Cell. 2023 Sep 25;58(18):1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011. Epub 2023 Jul 21. Dev Cell. 2023. PMID: 37480844
[No title available]
[No authors listed] [No authors listed] PMID: 34004780
Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration.
Arts JJ, Mahlandt EK, Grönloh ML, Schimmel L, Noordstra I, Gordon E, van Steen AC, Tol S, Walzog B, van Rijssel J, Nolte MA, Postma M, Khuon S, Heddleston JM, Wait E, Chew TL, Winter M, Montanez E, Goedhart J, van Buul JD. Arts JJ, et al. Among authors: schimmel l. Elife. 2021 Aug 25;10:e66074. doi: 10.7554/eLife.66074. Elife. 2021. PMID: 34431475 Free PMC article.
Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis.
Jin Y, Ding Y, Richards M, Kaakinen M, Giese W, Baumann E, Szymborska A, Rosa A, Nordling S, Schimmel L, Akmeriç EB, Pena A, Nwadozi E, Jamalpour M, Holstein K, Sáinz-Jaspeado M, Bernabeu MO, Welsh M, Gordon E, Franco CA, Vestweber D, Eklund L, Gerhardt H, Claesson-Welsh L. Jin Y, et al. Among authors: schimmel l. Nat Cardiovasc Res. 2022 Dec 7;1(12):1156-1173. doi: 10.1038/s44161-022-00172-z. Nat Cardiovasc Res. 2022. PMID: 37936984 Free PMC article.
Endothelial cells are not productively infected by SARS-CoV-2.
Schimmel L, Chew KY, Stocks CJ, Yordanov TE, Essebier P, Kulasinghe A, Monkman J, Dos Santos Miggiolaro AFR, Cooper C, de Noronha L, Schroder K, Lagendijk AK, Labzin LI, Short KR, Gordon EJ. Schimmel L, et al. Clin Transl Immunology. 2021 Oct 24;10(10):e1350. doi: 10.1002/cti2.1350. eCollection 2021. Clin Transl Immunology. 2021. PMID: 34721846 Free PMC article.
Stiffness-Induced Endothelial DLC-1 Expression Forces Leukocyte Spreading through Stabilization of the ICAM-1 Adhesome.
Schimmel L, van der Stoel M, Rianna C, van Stalborch AM, de Ligt A, Hoogenboezem M, Tol S, van Rijssel J, Szulcek R, Bogaard HJ, Hofmann P, Boon R, Radmacher M, de Waard V, Huveneers S, van Buul JD. Schimmel L, et al. Cell Rep. 2018 Sep 18;24(12):3115-3124. doi: 10.1016/j.celrep.2018.08.045. Cell Rep. 2018. PMID: 30231995 Free article.
33 results