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Discovery of Novel Oleamide Analogues as Brain-Penetrant Positive Allosteric Serotonin 5-HT2C Receptor and Dual 5-HT2C/5-HT2A Receptor Modulators.
Chen J, Garcia EJ, Merritt CR, Zamora JC, Bolinger AA, Pazdrak K, Stafford SJ, Mifflin RC, Wold EA, Wild CT, Chen H, Anastasio NC, Cunningham KA, Zhou J. Chen J, et al. Among authors: cunningham ka. J Med Chem. 2023 Jul 27;66(14):9992-10009. doi: 10.1021/acs.jmedchem.3c00908. Epub 2023 Jul 18. J Med Chem. 2023. PMID: 37462530 Free PMC article.
Selective serotonin 5-HT(2C) receptor activation suppresses the reinforcing efficacy of cocaine and sucrose but differentially affects the incentive-salience value of cocaine- vs. sucrose-associated cues.
Cunningham KA, Fox RG, Anastasio NC, Bubar MJ, Stutz SJ, Moeller FG, Gilbertson SR, Rosenzweig-Lipson S. Cunningham KA, et al. Neuropharmacology. 2011 Sep;61(3):513-23. doi: 10.1016/j.neuropharm.2011.04.034. Epub 2011 May 11. Neuropharmacology. 2011. PMID: 21575646 Free PMC article.
Peptide inhibitors disrupt the serotonin 5-HT2C receptor interaction with phosphatase and tensin homolog to allosterically modulate cellular signaling and behavior.
Anastasio NC, Gilbertson SR, Bubar MJ, Agarkov A, Stutz SJ, Jeng Y, Bremer NM, Smith TD, Fox RG, Swinford SE, Seitz PK, Charendoff MN, Craft JW Jr, Laezza FM, Watson CS, Briggs JM, Cunningham KA. Anastasio NC, et al. Among authors: cunningham ka. J Neurosci. 2013 Jan 23;33(4):1615-30. doi: 10.1523/JNEUROSCI.2656-12.2013. J Neurosci. 2013. PMID: 23345234 Free PMC article.
237 results