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Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults, a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
Stubbs BJ, Stephens EB, Senadheera C, Peralta S, Roa-Diaz S, Alexander L, Silverman-Martin W, Garcia TY, Yukawa M, Morris J, Blonquist TM, Johnson JB, Newman JC. Stubbs BJ, et al. medRxiv [Preprint]. 2024 May 5:2024.05.03.24306699. doi: 10.1101/2024.05.03.24306699. medRxiv. 2024. PMID: 38746215 Free PMC article. Preprint.
A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.
Stephens EB, Senadheera C, Roa-Diaz S, Peralta S, Alexander L, Silverman-Martin W, Yukawa M, Morris J, Johnson JB, Newman JC, Stubbs BJ. Stephens EB, et al. Among authors: stubbs bj. medRxiv [Preprint]. 2024 Apr 18:2024.04.16.24305925. doi: 10.1101/2024.04.16.24305925. medRxiv. 2024. PMID: 38699344 Free PMC article. Preprint.
Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
Stubbs BJ, Alvarez-Azanedo G, Peralta S, Roa-Diaz S, Gray W, Alexander L, Silverman-Martin W, Garcia T, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC. Stubbs BJ, et al. medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297571. doi: 10.1101/2023.10.25.23297571. medRxiv. 2023. PMID: 37961234 Free PMC article. Preprint.
Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons.
Barnes LL, Dhana K, Liu X, Carey VJ, Ventrelle J, Johnson K, Hollings CS, Bishop L, Laranjo N, Stubbs BJ, Reilly X, Agarwal P, Zhang S, Grodstein F, Tangney CC, Holland TM, Aggarwal NT, Arfanakis K, Morris MC, Sacks FM. Barnes LL, et al. Among authors: stubbs bj. N Engl J Med. 2023 Aug 17;389(7):602-611. doi: 10.1056/NEJMoa2302368. Epub 2023 Jul 18. N Engl J Med. 2023. PMID: 37466280 Free PMC article. Clinical Trial.
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.
Madhavan SS, Roa Diaz S, Peralta S, Nomura M, King CD, Lin A, Bhaumik D, Shah S, Blade T, Gray W, Chamoli M, Eap B, Panda O, Diaz D, Garcia TY, Stubbs BJ, Lithgow GJ, Schilling B, Verdin E, Chaudhuri AR, Newman JC. Madhavan SS, et al. Among authors: stubbs bj. bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547547. doi: 10.1101/2023.07.03.547547. bioRxiv. 2023. PMID: 37461525 Free PMC article. Preprint.
36 results