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Daily consumption of ketone ester, bis-octanoyl (R)-1,3-butanediol, is safe and tolerable in healthy older adults, a randomized, parallel arm, double-blind, placebo-controlled, pilot study.
medRxiv [Preprint]. 2024 May 5:2024.05.03.24306699. doi: 10.1101/2024.05.03.24306699.
medRxiv. 2024.
PMID: 38746215
Free PMC article.
Preprint.
A randomized open-label, observational study of the novel ketone ester, bis octanoyl (R)-1,3-butanediol, and its acute effect on ß-hydroxybutyrate and glucose concentrations in healthy older adults.
Stephens EB, Senadheera C, Roa-Diaz S, Peralta S, Alexander L, Silverman-Martin W, Yukawa M, Morris J, Johnson JB, Newman JC, Stubbs BJ.
Stephens EB, et al. Among authors: roa diaz s.
medRxiv [Preprint]. 2024 Apr 18:2024.04.16.24305925. doi: 10.1101/2024.04.16.24305925.
medRxiv. 2024.
PMID: 38699344
Free PMC article.
Preprint.
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Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis.
LaHue SC, Fuentealba M, Roa Diaz S, Seetharaman S, Garcia T, Furman D, Lai JC, Newman JC.
LaHue SC, et al. Among authors: roa diaz s.
Geroscience. 2024 Jun;46(3):3287-3295. doi: 10.1007/s11357-024-01076-5. Epub 2024 Jan 21.
Geroscience. 2024.
PMID: 38246968
Free PMC article.
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Rationale and protocol for a safety, tolerability and feasibility randomized, parallel group, double-blind, placebo-controlled, pilot study of a novel ketone ester targeting frailty via immunometabolic geroscience mechanisms.
Stubbs BJ, Alvarez-Azanedo G, Peralta S, Roa-Diaz S, Gray W, Alexander L, Silverman-Martin W, Garcia T, Blonquist TM, Upadhyay V, Turnbaugh PJ, Johnson JB, Newman JC.
Stubbs BJ, et al. Among authors: roa diaz s.
medRxiv [Preprint]. 2023 Oct 26:2023.10.25.23297571. doi: 10.1101/2023.10.25.23297571.
medRxiv. 2023.
PMID: 37961234
Free PMC article.
Preprint.
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β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain.
Madhavan SS, Roa Diaz S, Peralta S, Nomura M, King CD, Lin A, Bhaumik D, Shah S, Blade T, Gray W, Chamoli M, Eap B, Panda O, Diaz D, Garcia TY, Stubbs BJ, Lithgow GJ, Schilling B, Verdin E, Chaudhuri AR, Newman JC.
Madhavan SS, et al. Among authors: roa diaz s.
bioRxiv [Preprint]. 2023 Jul 3:2023.07.03.547547. doi: 10.1101/2023.07.03.547547.
bioRxiv. 2023.
PMID: 37461525
Free PMC article.
Preprint.
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Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults.
Crabtree CD, Blade T, Hyde PN, Buga A, Kackley ML, Sapper TN, Panda O, Roa-Diaz S, Anthony JC, Newman JC, Volek JS, Stubbs BJ.
Crabtree CD, et al. Among authors: roa diaz s.
J Am Nutr Assoc. 2023 Feb;42(2):169-177. doi: 10.1080/07315724.2021.2015476. Epub 2022 Mar 25.
J Am Nutr Assoc. 2023.
PMID: 35512774
Clinical Trial.
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