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Pharmacological modulation of Kv3 voltage-gated potassium channels regulates fear discrimination and expression in a response-dependent manner.
Stubbendorff C, Hale E, Day HLL, Smith J, Alvaro GS, Large CH, Stevenson CW. Stubbendorff C, et al. Among authors: large ch. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Dec 20;127:110829. doi: 10.1016/j.pnpbp.2023.110829. Epub 2023 Jul 12. Prog Neuropsychopharmacol Biol Psychiatry. 2023. PMID: 37451593 Free article.
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M. Liang Q, et al. Among authors: large ch. Nat Commun. 2024 Mar 21;15(1):2533. doi: 10.1038/s41467-024-46813-8. Nat Commun. 2024. PMID: 38514618 Free PMC article.
Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsy.
Feng H, Clatot J, Kaneko K, Flores-Mendez M, Wengert ER, Koutcher C, Hoddeson E, Lopez E, Lee D, Arias L, Liang Q, Zhang X, Somarowthu A, Covarrubias M, Gunthorpe MJ, Large CH, Akizu N, Goldberg EM. Feng H, et al. Among authors: large ch. Cell Rep Med. 2024 Feb 20;5(2):101389. doi: 10.1016/j.xcrm.2023.101389. Epub 2024 Jan 23. Cell Rep Med. 2024. PMID: 38266642 Free PMC article.
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.
Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, Burr K, Davies C, Colom-Cadena M, Chandran S, Large CH, Rowan MJM, Gunthorpe MJ, Spires-Jones TL. Yeap J, et al. Among authors: large ch. Brain Neurosci Adv. 2022 Mar 24;6:23982128221086464. doi: 10.1177/23982128221086464. eCollection 2022 Jan-Dec. Brain Neurosci Adv. 2022. PMID: 35359460 Free PMC article.
Why Is There No Cure for Tinnitus?
McFerran DJ, Stockdale D, Holme R, Large CH, Baguley DM. McFerran DJ, et al. Among authors: large ch. Front Neurosci. 2019 Aug 6;13:802. doi: 10.3389/fnins.2019.00802. eCollection 2019. Front Neurosci. 2019. PMID: 31447630 Free PMC article.
A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: The QUIET-1 trial.
Hall DA, Ray J, Watson J, Sharman A, Hutchison J, Harris P, Daniel M, Millar B, Large CH. Hall DA, et al. Among authors: large ch. Hear Res. 2019 Jun;377:153-166. doi: 10.1016/j.heares.2019.03.018. Epub 2019 Mar 27. Hear Res. 2019. PMID: 30939361 Free article. Clinical Trial.
53 results