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A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Among authors: melo isf. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145
Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema.
Godin AM, Araújo DP, Menezes RR, Brito AM, Melo IS, Coura GM, Soares DG, Bastos LF, Amaral FA, Ribeiro LS, Boff D, Santos JR, Santos DA, Teixeira MM, de Fátima Â, Machado RR, Coelho MM. Godin AM, et al. Pharmacol Biochem Behav. 2014 Jul;122:291-8. doi: 10.1016/j.pbb.2014.04.008. Epub 2014 Apr 26. Pharmacol Biochem Behav. 2014. PMID: 24780502
Anti-inflammatory and antinociceptive activities of azadirachtin in mice.
Soares DG, Godin AM, Menezes RR, Nogueira RD, Brito AM, Melo IS, Coura GM, Souza DG, Amaral FA, Paulino TP, Coelho MM, Machado RR. Soares DG, et al. Planta Med. 2014 Jun;80(8-9):630-6. doi: 10.1055/s-0034-1368507. Epub 2014 May 28. Planta Med. 2014. PMID: 24871207
Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms.
Godin AM, Araújo DP, César IC, Menezes RR, Brito AM, Melo IS, Coura GM, Bastos LF, Almeida MO, Byrro RM, Matsui TC, Batista CR, Pianetti GA, de Fátima Â, Machado RR, Coelho MM. Godin AM, et al. Eur J Pharmacol. 2015 Jun 5;756:59-66. doi: 10.1016/j.ejphar.2015.02.052. Epub 2015 Mar 17. Eur J Pharmacol. 2015. PMID: 25794846
2-Phthalimidethanol and 2-phthalimidethyl nitrate inhibit mechanical allodynia, neutrophil recruitment and cytokine and chemokine production in a murine model of articular inflammation.
Godin AM, Araújo DP, Menezes RR, de Brito AMS, Melo ISF, Coura GME, Bastos LFS, Amaral FA, Teixeira MM, de Fátima Â, Coelho MM, Machado RR. Godin AM, et al. Among authors: melo isf. Pharmacol Rep. 2017 Aug;69(4):691-695. doi: 10.1016/j.pharep.2017.01.033. Epub 2017 Feb 8. Pharmacol Rep. 2017. PMID: 28550800
Thiamine and riboflavin inhibit production of cytokines and increase the anti-inflammatory activity of a corticosteroid in a chronic model of inflammation induced by complete Freund's adjuvant.
Menezes RR, Godin AM, Rodrigues FF, Coura GME, Melo ISF, Brito AMS, Bertollo CM, Paulino TP, Rachid MA, Machado RR, Coelho MM. Menezes RR, et al. Among authors: melo isf. Pharmacol Rep. 2017 Oct;69(5):1036-1043. doi: 10.1016/j.pharep.2017.04.011. Epub 2017 Apr 23. Pharmacol Rep. 2017. PMID: 28958614
Antiallodynic activity of leflunomide is partially inhibited by naltrexone and glibenclamide and associated with reduced production of TNF-α and CXCL-1.
Brito AMS, Godin AM, Augusto PSA, Menezes RR, Melo ISF, Dutra MGMB, Costa SOAM, Goulart FA, Rodrigues FF, Ísis Morais M, Machado RR, Coelho MM. Brito AMS, et al. Among authors: melo isf. Eur J Pharmacol. 2018 Jan 5;818:17-25. doi: 10.1016/j.ejphar.2017.10.026. Epub 2017 Oct 16. Eur J Pharmacol. 2018. PMID: 29042208
22 results