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A clindamycin acetylated derivative with reduced antibacterial activity inhibits articular hyperalgesia and edema by attenuating neutrophil recruitment, NF-κB activation and tumor necrosis factor-α production.
Rodrigues FF, Lino CI, Oliveira VLS, Zaidan I, Melo ISF, Braga AV, Costa SOAM, Morais MI, Barbosa BCM, da Costa YFG, Moreira NF, Alves MS, Braga AD, Carneiro FS, Carvalho AFS, Queiroz-Junior CM, Sousa LP, Amaral FA, Oliveira RB, Coelho MM, Machado RR. Rodrigues FF, et al. Among authors: machado rr. Int Immunopharmacol. 2023 Sep;122:110609. doi: 10.1016/j.intimp.2023.110609. Epub 2023 Jul 8. Int Immunopharmacol. 2023. PMID: 37429145
A minocycline derivative reduces nerve injury-induced allodynia, LPS-induced prostaglandin E2 microglial production and signaling via toll-like receptors 2 and 4.
Bastos LF, Godin AM, Zhang Y, Jarussophon S, Ferreira BC, Machado RR, Maier SF, Konishi Y, de Freitas RP, Fiebich BL, Watkins LR, Coelho MM, Moraes MF. Bastos LF, et al. Among authors: machado rr. Neurosci Lett. 2013 May 24;543:157-62. doi: 10.1016/j.neulet.2013.03.014. Epub 2013 Mar 21. Neurosci Lett. 2013. PMID: 23523650 Free PMC article.
Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Dutra MM, Godin AM, César IC, Nascimento EB Jr, Menezes RR, Ferreira WC, Soares DG, Seniuk JG, Araújo DP, Bastos LF, Pianetti GA, de Fátima Â, Machado RR, Coelho MM. Dutra MM, et al. Among authors: machado rr. Pharmacol Biochem Behav. 2013 May;106:85-90. doi: 10.1016/j.pbb.2013.03.004. Epub 2013 Mar 26. Pharmacol Biochem Behav. 2013. PMID: 23537730 Free article.
Activities of 2-phthalimidethanol and 2-phthalimidethyl nitrate, phthalimide analogs devoid of the glutarimide moiety, in experimental models of inflammatory pain and edema.
Godin AM, Araújo DP, Menezes RR, Brito AM, Melo IS, Coura GM, Soares DG, Bastos LF, Amaral FA, Ribeiro LS, Boff D, Santos JR, Santos DA, Teixeira MM, de Fátima Â, Machado RR, Coelho MM. Godin AM, et al. Among authors: machado rr. Pharmacol Biochem Behav. 2014 Jul;122:291-8. doi: 10.1016/j.pbb.2014.04.008. Epub 2014 Apr 26. Pharmacol Biochem Behav. 2014. PMID: 24780502
Anti-inflammatory and antinociceptive activities of azadirachtin in mice.
Soares DG, Godin AM, Menezes RR, Nogueira RD, Brito AM, Melo IS, Coura GM, Souza DG, Amaral FA, Paulino TP, Coelho MM, Machado RR. Soares DG, et al. Among authors: machado rr. Planta Med. 2014 Jun;80(8-9):630-6. doi: 10.1055/s-0034-1368507. Epub 2014 May 28. Planta Med. 2014. PMID: 24871207
Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms.
Godin AM, Araújo DP, César IC, Menezes RR, Brito AM, Melo IS, Coura GM, Bastos LF, Almeida MO, Byrro RM, Matsui TC, Batista CR, Pianetti GA, de Fátima Â, Machado RR, Coelho MM. Godin AM, et al. Among authors: machado rr. Eur J Pharmacol. 2015 Jun 5;756:59-66. doi: 10.1016/j.ejphar.2015.02.052. Epub 2015 Mar 17. Eur J Pharmacol. 2015. PMID: 25794846
114 results