Penning TM - Search Results

1

Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model.

Maddeboina K, Jonnalagadda SK, Morsy A, Duan L, Chhonker YS, Murry DJ, Penning TM, Trippier PC. Maddeboina K, et al. Among authors: penning tm. J Med Chem. 2023 Jul 27;66(14):9894-9915. doi: 10.1021/acs.jmedchem.3c00732. Epub 2023 Jul 10. J Med Chem. 2023. PMID: 37428858

2

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

Steckelbroeck S, Jin Y, Gopishetty S, Oyesanmi B, Penning TM. Steckelbroeck S, et al. Among authors: penning tm. J Biol Chem. 2004 Mar 12;279(11):10784-95. doi: 10.1074/jbc.M313308200. Epub 2003 Dec 12. J Biol Chem. 2004. PMID: 14672942 Free article.

3

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

Jin Y, Duan L, Lee SH, Kloosterboer HJ, Blair IA, Penning TM. Jin Y, et al. Among authors: penning tm. J Biol Chem. 2009 Apr 10;284(15):10013-22. doi: 10.1074/jbc.M809465200. Epub 2009 Feb 12. J Biol Chem. 2009. PMID: 19218247 Free PMC article.

4

Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.

Byrns MC, Duan L, Lee SH, Blair IA, Penning TM. Byrns MC, et al. Among authors: penning tm. J Steroid Biochem Mol Biol. 2010 Feb 15;118(3):177-87. doi: 10.1016/j.jsbmb.2009.12.009. Epub 2009 Dec 28. J Steroid Biochem Mol Biol. 2010. PMID: 20036328 Free PMC article.

5

Discovery of substituted 3-(phenylamino)benzoic acids as potent and selective inhibitors of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

Adeniji AO, Twenter BM, Byrns MC, Jin Y, Winkler JD, Penning TM. Adeniji AO, et al. Among authors: penning tm. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1464-8. doi: 10.1016/j.bmcl.2011.01.010. Epub 2011 Jan 7. Bioorg Med Chem Lett. 2011. PMID: 21277203 Free PMC article.

6

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily.

Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. Jin Y, et al. Among authors: penning tm. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):139-44. doi: 10.1016/j.jsbmb.2011.12.002. Epub 2011 Dec 28. J Steroid Biochem Mol Biol. 2012. PMID: 22210085 Free PMC article.

7

Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships.

Adeniji AO, Twenter BM, Byrns MC, Jin Y, Chen M, Winkler JD, Penning TM. Adeniji AO, et al. Among authors: penning tm. J Med Chem. 2012 Mar 8;55(5):2311-23. doi: 10.1021/jm201547v. Epub 2012 Feb 15. J Med Chem. 2012. PMID: 22263837 Free PMC article.

8

Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride.

Byrns MC, Mindnich R, Duan L, Penning TM. Byrns MC, et al. Among authors: penning tm. J Steroid Biochem Mol Biol. 2012 May;130(1-2):7-15. doi: 10.1016/j.jsbmb.2011.12.012. Epub 2012 Jan 12. J Steroid Biochem Mol Biol. 2012. PMID: 22265960 Free PMC article.

9

Crystal structures of AKR1C3 containing an N-(aryl)amino-benzoate inhibitor and a bifunctional AKR1C3 inhibitor and androgen receptor antagonist. Therapeutic leads for castrate resistant prostate cancer.

Chen M, Adeniji AO, Twenter BM, Winkler JD, Christianson DW, Penning TM. Chen M, et al. Among authors: penning tm. Bioorg Med Chem Lett. 2012 May 15;22(10):3492-7. doi: 10.1016/j.bmcl.2012.03.085. Epub 2012 Mar 29. Bioorg Med Chem Lett. 2012. PMID: 22507964 Free PMC article.

10

Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3).

Zang T, Verma K, Chen M, Jin Y, Trippier PC, Penning TM. Zang T, et al. Among authors: penning tm. Chem Biol Interact. 2015 Jun 5;234:339-48. doi: 10.1016/j.cbi.2014.12.015. Epub 2014 Dec 31. Chem Biol Interact. 2015. PMID: 25555457 Free PMC article.

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