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Discovery of small molecule entry inhibitors targeting the linoleic acid binding pocket of SARS-CoV-2 spike protein.
Prasad R, Kadam A, Padippurackal VV, Pulikuttymadom Balasubramanian A, Kumar Chandrakumaran N, Suresh Rangari K, Dnyaneshwar Khangar P, Ajith H, Natarajan K, Chandramohanadas R, Nelson-Sathi S. Prasad R, et al. Among authors: chandramohanadas r. J Biomol Struct Dyn. 2024 Mar 23:1-15. doi: 10.1080/07391102.2024.2327537. Online ahead of print. J Biomol Struct Dyn. 2024. PMID: 38520147
Optical diffraction tomography and image reconstruction to measure host cell alterations caused by divergent Plasmodium species.
Ong JJY, Oh J, Yong Ang X, Naidu R, Chu TTT, Hyoung Im J, Manzoor U, Kha Nguyen T, Na SW, Han ET, Davis C, Sun Park W, Chun W, Jun H, Jin Lee S, Na S, Chan JKY, Park Y, Russell B, Chandramohanadas R, Han JH. Ong JJY, et al. Among authors: chandramohanadas r. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Feb 5;286:122026. doi: 10.1016/j.saa.2022.122026. Epub 2022 Oct 22. Spectrochim Acta A Mol Biomol Spectrosc. 2023. PMID: 36395614 Free article.
High-Content Phenotypic Screen of a Focused TCAMS Drug Library Identifies Novel Disruptors of the Malaria Parasite Calcium Dynamics.
Chia W, Gomez-Lorenzo MG, Castellote I, Tong JX, Chandramohanadas R, Thu Chu TT, Shen W, Go ML, de Cozar C, Crespo B, Almela MJ, Neria-Serrano F, Franco V, Gamo FJ, Tan KSW. Chia W, et al. Among authors: chandramohanadas r. ACS Chem Biol. 2021 Nov 19;16(11):2348-2372. doi: 10.1021/acschembio.1c00512. Epub 2021 Oct 5. ACS Chem Biol. 2021. PMID: 34609851
Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells.
Malleret B, El Sahili A, Tay MZ, Carissimo G, Ong ASM, Novera W, Lin J, Suwanarusk R, Kosaisavee V, Chu TTT, Sinha A, Howland SW, Fan Y, Gruszczyk J, Tham WH, Colin Y, Maurer-Stroh S, Snounou G, Ng LFP, Chan JKY, Chacko AM, Lescar J, Chandramohanadas R, Nosten F, Russell B, Rénia L. Malleret B, et al. Among authors: chandramohanadas r. Nat Microbiol. 2021 Aug;6(8):991-999. doi: 10.1038/s41564-021-00939-3. Epub 2021 Jul 22. Nat Microbiol. 2021. PMID: 34294905
Whole-Cell Phenotypic Screening of Medicines for Malaria Venture Pathogen Box Identifies Specific Inhibitors of Plasmodium falciparum Late-Stage Development and Egress.
Patra AT, Hingamire T, Belekar MA, Xiong A, Subramanian G, Bozdech Z, Preiser P, Shanmugam D, Chandramohanadas R. Patra AT, et al. Among authors: chandramohanadas r. Antimicrob Agents Chemother. 2020 Apr 21;64(5):e01802-19. doi: 10.1128/AAC.01802-19. Print 2020 Apr 21. Antimicrob Agents Chemother. 2020. PMID: 32071059 Free PMC article.
32 results