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In vivo evolution of a Klebsiella pneumoniae capsule defect promotes complement-mediated opsono-phagocytosis and persistence during recurrent infection.
Bain W, Ahn B, Peñaloza HF, McElheny CL, Tolman N, van der Geest R, Gonzalez-Ferrer S, Chen N, An X, Hosuru R, Tabary M, Papke E, Kohli N, Farooq N, Bachman W, Olonisakin TF, Xiong Z, Griffith MP, Sullivan M, Franks J, Mustapha MM, Iovleva A, Suber T, Shanks RQ, Ferreira VP, Stolz DB, Van Tyne D, Doi Y, Lee JS. Bain W, et al. Among authors: franks j. bioRxiv [Preprint]. 2023 Jun 1:2023.05.31.542722. doi: 10.1101/2023.05.31.542722. bioRxiv. 2023. PMID: 37398264 Free PMC article. Updated. Preprint.
Phagocytosis is a primary determinant of pulmonary clearance of clinical Klebsiella pneumoniae isolates.
van der Geest R, Fan H, Peñaloza HF, Bain WG, Xiong Z, Kohli N, Larson E, Sullivan MLG, Franks JM, Stolz DB, Ito R, Chen K, Doi Y, Harriff MJ, Lee JS. van der Geest R, et al. Among authors: franks jm. Front Cell Infect Microbiol. 2023 Mar 28;13:1150658. doi: 10.3389/fcimb.2023.1150658. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37056705 Free PMC article.
Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types.
Maggiore JC, LeGraw R, Przepiorski A, Velazquez J, Chaney C, Streeter E, Silva-Barbosa A, Franks J, Hislop J, Hill A, Wu H, Pfister K, Howden SE, Watkins SC, Little M, Humphreys BD, Watson A, Stolz DB, Kiani S, Davidson AJ, Carroll TJ, Cleaver O, Sims-Lucas S, Ebrahimkhani MR, Hukriede NA. Maggiore JC, et al. Among authors: franks j. bioRxiv [Preprint]. 2023 May 30:2023.05.30.542848. doi: 10.1101/2023.05.30.542848. bioRxiv. 2023. PMID: 37333155 Free PMC article. Preprint.
In vivo evolution of a Klebsiella pneumoniae capsule defect with wcaJ mutation promotes complement-mediated opsono-phagocytosis during recurrent infection.
Bain W, Ahn B, Peñaloza HF, McElheny CL, Tolman N, van der Geest R, Gonzalez-Ferrer S, Chen N, An X, Hosuru R, Tabary M, Papke E, Kohli N, Farooq N, Bachman W, Olonisakin TF, Xiong Z, Griffith MP, Sullivan M, Franks J, Mustapha MM, Iovleva A, Suber T, Shanks RQ, Ferreira VP, Stolz DB, Van Tyne D, Doi Y, Lee JS. Bain W, et al. Among authors: franks j. J Infect Dis. 2024 Jan 25:jiae003. doi: 10.1093/infdis/jiae003. Online ahead of print. J Infect Dis. 2024. PMID: 38271564
WNK kinases sense molecular crowding and rescue cell volume via phase separation.
Boyd-Shiwarski CR, Shiwarski DJ, Griffiths SE, Beacham RT, Norrell L, Morrison DE, Wang J, Mann J, Tennant W, Anderson EN, Franks J, Calderon M, Connolly KA, Cheema MU, Weaver CJ, Nkashama LJ, Weckerly CC, Querry KE, Pandey UB, Donnelly CJ, Sun D, Rodan AR, Subramanya AR. Boyd-Shiwarski CR, et al. Among authors: franks j. Cell. 2022 Nov 23;185(24):4488-4506.e20. doi: 10.1016/j.cell.2022.09.042. Epub 2022 Oct 31. Cell. 2022. PMID: 36318922 Free PMC article.
346 results