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Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease.
Broughton SE, Petersen J, Theodossis A, Scally SW, Loh KL, Thompson A, van Bergen J, Kooy-Winkelaar Y, Henderson KN, Beddoe T, Tye-Din JA, Mannering SI, Purcell AW, McCluskey J, Anderson RP, Koning F, Reid HH, Rossjohn J. Broughton SE, et al. Among authors: loh kl. Immunity. 2012 Oct 19;37(4):611-21. doi: 10.1016/j.immuni.2012.07.013. Epub 2012 Oct 11. Immunity. 2012. PMID: 23063329 Free article.
T-cell receptor recognition of HLA-DQ2-gliadin complexes associated with celiac disease.
Petersen J, Montserrat V, Mujico JR, Loh KL, Beringer DX, van Lummel M, Thompson A, Mearin ML, Schweizer J, Kooy-Winkelaar Y, van Bergen J, Drijfhout JW, Kan WT, La Gruta NL, Anderson RP, Reid HH, Koning F, Rossjohn J. Petersen J, et al. Among authors: loh kl. Nat Struct Mol Biol. 2014 May;21(5):480-8. doi: 10.1038/nsmb.2817. Epub 2014 Apr 28. Nat Struct Mol Biol. 2014. PMID: 24777060
T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.
Beringer DX, Kleijwegt FS, Wiede F, van der Slik AR, Loh KL, Petersen J, Dudek NL, Duinkerken G, Laban S, Joosten A, Vivian JP, Chen Z, Uldrich AP, Godfrey DI, McCluskey J, Price DA, Radford KJ, Purcell AW, Nikolic T, Reid HH, Tiganis T, Roep BO, Rossjohn J. Beringer DX, et al. Among authors: loh kl. Nat Immunol. 2015 Nov;16(11):1153-61. doi: 10.1038/ni.3271. Epub 2015 Oct 5. Nat Immunol. 2015. PMID: 26437244
Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR. Ooi JD, et al. Among authors: loh kl. Nature. 2017 May 11;545(7653):243-247. doi: 10.1038/nature22329. Epub 2017 May 3. Nature. 2017. PMID: 28467828 Free PMC article.
A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity.
Ooi JD, Jiang JH, Eggenhuizen PJ, Chua LL, van Timmeren M, Loh KL, O'Sullivan KM, Gan PY, Zhong Y, Tsyganov K, Shochet LR, Ryan J, Stegeman CA, Fugger L, Reid HH, Rossjohn J, Heeringa P, Holdsworth SR, Peleg AY, Kitching AR. Ooi JD, et al. Among authors: loh kl. Nat Commun. 2019 Jul 29;10(1):3392. doi: 10.1038/s41467-019-11255-0. Nat Commun. 2019. PMID: 31358739 Free PMC article.
T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Petersen J, Ciacchi L, Tran MT, Loh KL, Kooy-Winkelaar Y, Croft NP, Hardy MY, Chen Z, McCluskey J, Anderson RP, Purcell AW, Tye-Din JA, Koning F, Reid HH, Rossjohn J. Petersen J, et al. Among authors: loh kl. Nat Struct Mol Biol. 2020 Jan;27(1):49-61. doi: 10.1038/s41594-019-0353-4. Epub 2019 Dec 23. Nat Struct Mol Biol. 2020. PMID: 31873306
The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR.
Lim JJ, Jones CM, Loh TJ, Ting YT, Zareie P, Loh KL, Felix NJ, Suri A, McKinnon M, Stevenaert F, Sharma RK, Klareskog L, Malmström V, Baker DG, Purcell AW, Reid HH, La Gruta NL, Rossjohn J. Lim JJ, et al. Among authors: loh kl. Sci Immunol. 2021 Apr 16;6(58):eabe0896. doi: 10.1126/sciimmunol.abe0896. Sci Immunol. 2021. PMID: 33863750
Smith-specific regulatory T cells halt the progression of lupus nephritis.
Eggenhuizen PJ, Cheong RMY, Lo C, Chang J, Ng BH, Ting YT, Monk JA, Loh KL, Broury A, Tay ESV, Shen C, Zhong Y, Lim S, Chung JX, Kandane-Rathnayake R, Koelmeyer R, Hoi A, Chaudhry A, Manzanillo P, Snelgrove SL, Morand EF, Ooi JD. Eggenhuizen PJ, et al. Among authors: loh kl. Nat Commun. 2024 Feb 6;15(1):899. doi: 10.1038/s41467-024-45056-x. Nat Commun. 2024. PMID: 38321013 Free PMC article.
22 results