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The SEURAT-1 approach towards animal free human safety assessment.
Gocht T, Berggren E, Ahr HJ, Cotgreave I, Cronin MT, Daston G, Hardy B, Heinzle E, Hescheler J, Knight DJ, Mahony C, Peschanski M, Schwarz M, Thomas RS, Verfaillie C, White A, Whelan M. Gocht T, et al. Among authors: ahr hj. ALTEX. 2015;32(1):9-24. doi: 10.14573/altex.1408041. Epub 2014 Nov 5. ALTEX. 2015. PMID: 25372315 Free article.
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes.
Schug M, Stöber R, Heise T, Mielke H, Gundert-Remy U, Godoy P, Reif R, Blaszkewicz M, Ellinger-Ziegelbauer H, Ahr HJ, Selinski S, Günther G, Marchan R, Blaszkewicz M, Sachinidis A, Nüssler A, Oberemm A, Hengstler JG. Schug M, et al. Among authors: ahr hj. Arch Toxicol. 2013 Feb;87(2):337-45. doi: 10.1007/s00204-012-0999-8. Epub 2012 Dec 29. Arch Toxicol. 2013. PMID: 23274394
In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens.
Heise T, Schug M, Storm D, Ellinger-Ziegelbauer H, Ahr HJ, Hellwig B, Rahnenfuhrer J, Ghallab A, Guenther G, Sisnaiske J, Reif R, Godoy P, Mielke H, Gundert-Remy U, Lampen A, Oberemm A, Hengstler JG. Heise T, et al. Among authors: ahr hj. Curr Med Chem. 2012;19(11):1721-30. doi: 10.2174/092986712799945049. Curr Med Chem. 2012. PMID: 22414088
Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model.
Jennings P, Weiland C, Limonciel A, Bloch KM, Radford R, Aschauer L, McMorrow T, Wilmes A, Pfaller W, Ahr HJ, Slattery C, Lock EA, Ryan MP, Ellinger-Ziegelbauer H. Jennings P, et al. Among authors: ahr hj. Arch Toxicol. 2012 Apr;86(4):571-89. doi: 10.1007/s00204-011-0780-4. Epub 2011 Nov 29. Arch Toxicol. 2012. PMID: 22124623
Assessment of a robust model protocol with accelerated throughput for a human recombinant full length estrogen receptor-alpha binding assay: protocol optimization and intralaboratory assay performance as initial steps towards validation.
Freyberger A, Wilson V, Weimer M, Tan S, Tran HS, Ahr HJ. Freyberger A, et al. Among authors: ahr hj. Reprod Toxicol. 2010 Aug;30(1):50-9. doi: 10.1016/j.reprotox.2010.01.001. Epub 2010 Jan 13. Reprod Toxicol. 2010. PMID: 20074635
Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics.
Steimer JL, Dahl SG, De Alwis DP, Gundert-Remy U, Karlsson MO, Martinkova J, Aarons L, Ahr HJ, Clairambault J, Freyer G, Friberg LE, Kern SE, Kopp-Schneider A, Ludwig WD, De Nicolao G, Rocchetti M, Troconiz IF. Steimer JL, et al. Among authors: ahr hj. Eur J Cancer. 2010 Jan;46(1):21-32. doi: 10.1016/j.ejca.2009.10.011. Eur J Cancer. 2010. PMID: 19954965
81 results