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Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung.
Li J, de Melo Jorge DM, Wang W, Sun S, Frum T, Hang YA, Liu Y, Zhou X, Xiao J, Wang X, Spence JR, Wobus CE, Zhu HJ. Li J, et al. Among authors: spence jr. J Med Chem. 2024 May 9;67(9):7470-7486. doi: 10.1021/acs.jmedchem.4c00234. Epub 2024 May 1. J Med Chem. 2024. PMID: 38690769
A patterned human neural tube model using microfluidic gradients.
Xue X, Kim YS, Ponce-Arias AI, O'Laughlin R, Yan RZ, Kobayashi N, Tshuva RY, Tsai YH, Sun S, Zheng Y, Liu Y, Wong FCK, Surani A, Spence JR, Song H, Ming GL, Reiner O, Fu J. Xue X, et al. Among authors: spence jr. Nature. 2024 Apr;628(8007):391-399. doi: 10.1038/s41586-024-07204-7. Epub 2024 Feb 26. Nature. 2024. PMID: 38408487
Stably-Inverted Apical-Out Human Upper Airway Organoids for SARS-CoV-2 Infection and Therapeutic Testing.
Lee JH, LeCher JC, Parigoris E, Shinagawa N, Sentosa J, Manfredi C, Goh SL, De R, Tao S, Zandi K, Amblard F, Sorscher EJ, Spence JR, Tirouvanziam R, Schinazi RF, Takayama S. Lee JH, et al. Among authors: spence jr. bioRxiv [Preprint]. 2024 Jan 4:2024.01.02.573939. doi: 10.1101/2024.01.02.573939. bioRxiv. 2024. PMID: 38260306 Free PMC article. Preprint.
Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection.
Bragazzi Cunha J, Leix K, Sherman EJ, Mirabelli C, Frum T, Zhang CJ, Kennedy AA, Lauring AS, Tai AW, Sexton JZ, Spence JR, Wobus CE, Emmer BT. Bragazzi Cunha J, et al. Among authors: spence jr. J Virol. 2023 Dec 21;97(12):e0127623. doi: 10.1128/jvi.01276-23. Epub 2023 Nov 17. J Virol. 2023. PMID: 37975674 Free PMC article.
Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon.
Múnera JO, Kechele DO, Bouffi C, Qu N, Jing R, Maity P, Enriquez JR, Han L, Campbell I, Mahe MM, McCauley HA, Zhang X, Sundaram N, Hudson JR, Zarsozo-Lacoste A, Pradhan S, Tominaga K, Sanchez JG, Weiss AA, Chatuvedi P, Spence JR, Hachimi M, North T, Daley GQ, Mayhew CN, Hu YC, Takebe T, Helmrath MA, Wells JM. Múnera JO, et al. Among authors: spence jr. Cell Stem Cell. 2023 Nov 2;30(11):1434-1451.e9. doi: 10.1016/j.stem.2023.10.002. Cell Stem Cell. 2023. PMID: 37922878 Free PMC article.
212 results