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Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design.
Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Funk LM, et al. Among authors: tittmann k. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. Nat Commun. 2024. PMID: 38195625 Free PMC article.
Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.
Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J. Hicks KG, et al. Among authors: tittmann k. Science. 2023 Mar 10;379(6636):996-1003. doi: 10.1126/science.abm3452. Epub 2023 Mar 9. Science. 2023. PMID: 36893255 Free PMC article.
19F Electron-Nuclear Double Resonance Reveals Interaction between Redox-Active Tyrosines across the α/β Interface of E. coli Ribonucleotide Reductase.
Meyer A, Kehl A, Cui C, Reichardt FAK, Hecker F, Funk LM, Ghosh MK, Pan KT, Urlaub H, Tittmann K, Stubbe J, Bennati M. Meyer A, et al. Among authors: tittmann k. J Am Chem Soc. 2022 Jun 29;144(25):11270-11282. doi: 10.1021/jacs.2c02906. Epub 2022 Jun 2. J Am Chem Soc. 2022. PMID: 35652913 Free PMC article.
Lysines and cysteines: partners in stress?
Rabe von Pappenheim F, Tittmann K. Rabe von Pappenheim F, et al. Among authors: tittmann k. Trends Biochem Sci. 2022 May;47(5):372-374. doi: 10.1016/j.tibs.2022.02.006. Trends Biochem Sci. 2022. PMID: 35427478
Widespread occurrence of covalent lysine-cysteine redox switches in proteins.
Rabe von Pappenheim F, Wensien M, Ye J, Uranga J, Irisarri I, de Vries J, Funk LM, Mata RA, Tittmann K. Rabe von Pappenheim F, et al. Among authors: tittmann k. Nat Chem Biol. 2022 Apr;18(4):368-375. doi: 10.1038/s41589-021-00966-5. Epub 2022 Feb 14. Nat Chem Biol. 2022. PMID: 35165445 Free PMC article.
87 results