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Mammalian target of rapamycin complex 2 (mTORC2) coordinates pulmonary artery smooth muscle cell metabolism, proliferation, and survival in pulmonary arterial hypertension.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. Goncharov DA, et al. Among authors: goncharova ea. Circulation. 2014 Feb 25;129(8):864-74. doi: 10.1161/CIRCULATIONAHA.113.004581. Epub 2013 Nov 22. Circulation. 2014. PMID: 24270265 Free PMC article.
HIPPO-Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension.
Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HH, Shapiro S, Zhao Y, Goncharova EA. Kudryashova TV, et al. Among authors: goncharova ea. Am J Respir Crit Care Med. 2016 Oct 1;194(7):866-877. doi: 10.1164/rccm.201510-2003OC. Am J Respir Crit Care Med. 2016. PMID: 27119551 Free PMC article.
Translational Advances in the Field of Pulmonary Hypertension. From Cancer Biology to New Pulmonary Arterial Hypertension Therapeutics. Targeting Cell Growth and Proliferation Signaling Hubs.
Pullamsetti SS, Savai R, Seeger W, Goncharova EA. Pullamsetti SS, et al. Among authors: goncharova ea. Am J Respir Crit Care Med. 2017 Feb 15;195(4):425-437. doi: 10.1164/rccm.201606-1226PP. Am J Respir Crit Care Med. 2017. PMID: 27627135 Free PMC article. Review. No abstract available.
Pharmacological Inhibition of mTOR Kinase Reverses Right Ventricle Remodeling and Improves Right Ventricle Structure and Function in Rats.
Pena A, Kobir A, Goncharov D, Goda A, Kudryashova TV, Ray A, Vanderpool R, Baust J, Chang B, Mora AL, Gorcsan J 3rd, Goncharova EA. Pena A, et al. Among authors: goncharova ea. Am J Respir Cell Mol Biol. 2017 Nov;57(5):615-625. doi: 10.1165/rcmb.2016-0364OC. Am J Respir Cell Mol Biol. 2017. PMID: 28679058 Free PMC article.
Inhibitory Antibodies against Activin A and TGF-β Reduce Self-Supported, but Not Soluble Factors-Induced Growth of Human Pulmonary Arterial Vascular Smooth Muscle Cells in Pulmonary Arterial Hypertension.
Kudryashova TV, Shen Y, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA. Kudryashova TV, et al. Among authors: goncharova ea. Int J Mol Sci. 2018 Sep 28;19(10):2957. doi: 10.3390/ijms19102957. Int J Mol Sci. 2018. PMID: 30274147 Free PMC article.
Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure.
Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM. Spiekerkoetter E, et al. Among authors: goncharova ea. Pulm Circ. 2019 Nov 20;9(4):2045894019889775. doi: 10.1177/2045894019889775. eCollection 2019 Oct-Dec. Pulm Circ. 2019. PMID: 31798835 Free PMC article.
98 results