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Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation.
Orozco CT, Edgeworth MJ, Devine PWA, Hines AR, Cornwell O, Thompson C, Wang X, Phillips JJ, Ravn P, Jackson SE, Bond NJ. Orozco CT, et al. Among authors: bond nj. Bioconjug Chem. 2021 Aug 18;32(8):1834-1844. doi: 10.1021/acs.bioconjchem.1c00286. Epub 2021 Aug 9. Bioconjug Chem. 2021. PMID: 34369158 Free article.
Mechanistic insights into the rational design of masked antibodies.
Orozco CT, Bersellini M, Irving LM, Howard WW, Hargreaves D, Devine PWA, Siouve E, Browne GJ, Bond NJ, Phillips JJ, Ravn P, Jackson SE. Orozco CT, et al. Among authors: bond nj. MAbs. 2022 Jan-Dec;14(1):2095701. doi: 10.1080/19420862.2022.2095701. MAbs. 2022. PMID: 35799328 Free PMC article.
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling.
Kapustin AN, Davey P, Longmire D, Matthews C, Linnane E, Rustogi N, Stavrou M, Devine PWA, Bond NJ, Hanson L, Sonzini S, Revenko A, MacLeod AR, Ross S, Chiarparin E, Puri S. Kapustin AN, et al. Among authors: bond nj. Commun Biol. 2021 Nov 1;4(1):1241. doi: 10.1038/s42003-021-02772-0. Commun Biol. 2021. PMID: 34725463 Free PMC article.
An in vivo platform to select and evolve aggregation-resistant proteins.
Ebo JS, Saunders JC, Devine PWA, Gordon AM, Warwick AS, Schiffrin B, Chin SE, England E, Button JD, Lloyd C, Bond NJ, Ashcroft AE, Radford SE, Lowe DC, Brockwell DJ. Ebo JS, et al. Among authors: bond nj. Nat Commun. 2020 Apr 14;11(1):1816. doi: 10.1038/s41467-020-15667-1. Nat Commun. 2020. PMID: 32286330 Free PMC article.
33 results