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CD24 targeting with NK-CAR immunotherapy in testis, prostate, renal and (luminal-type) bladder cancer and identification of direct CD24 interaction partners.
Söhngen C, Thomas DJ, Skowron MA, Bremmer F, Eckstein M, Stefanski A, Driessen MD, Wakileh GA, Stühler K, Altevogt P, Theodorescu D, Klapdor R, Schambach A, Nettersheim D. Söhngen C, et al. Among authors: skowron ma. FEBS J. 2023 Oct;290(20):4864-4876. doi: 10.1111/febs.16880. Epub 2023 Jun 26. FEBS J. 2023. PMID: 37254618
ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 while ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell Tumor Cells to ATR Inhibition.
Kurz L, Miklyaeva A, Skowron MA, Overbeck N, Poschmann G, Becker T, Eul K, Kurz T, Schönberger S, Calaminus G, Stühler K, Dykhuizen E, Albers P, Nettersheim D. Kurz L, et al. Among authors: skowron ma. Cancers (Basel). 2020 Apr 7;12(4):905. doi: 10.3390/cancers12040905. Cancers (Basel). 2020. PMID: 32272809 Free PMC article.
CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.
Skowron MA, Vermeulen M, Winkelhausen A, Becker TK, Bremmer F, Petzsch P, Schönberger S, Calaminus G, Köhrer K, Albers P, Nettersheim D. Skowron MA, et al. Br J Cancer. 2020 Aug;123(3):378-391. doi: 10.1038/s41416-020-0891-x. Epub 2020 May 18. Br J Cancer. 2020. PMID: 32418994 Free PMC article.
The pioneer and differentiation factor FOXA2 is a key driver of yolk-sac tumour formation and a new biomarker for paediatric and adult yolk-sac tumours.
Wruck W, Bremmer F, Kotthoff M, Fichtner A, Skowron MA, Schönberger S, Calaminus G, Vokuhl C, Pfister D, Heidenreich A, Albers P, Adjaye J, Nettersheim D. Wruck W, et al. Among authors: skowron ma. J Cell Mol Med. 2021 Feb;25(3):1394-1405. doi: 10.1111/jcmm.16222. Epub 2021 Jan 14. J Cell Mol Med. 2021. PMID: 33448076 Free PMC article.
Molecular and epigenetic pathogenesis of germ cell tumors.
Müller MR, Skowron MA, Albers P, Nettersheim D. Müller MR, et al. Among authors: skowron ma. Asian J Urol. 2021 Apr;8(2):144-154. doi: 10.1016/j.ajur.2020.05.009. Epub 2020 May 30. Asian J Urol. 2021. PMID: 33996469 Free PMC article. Review.
The signal transducer CD24 suppresses the germ cell program and promotes an ectodermal rather than mesodermal cell fate in embryonal carcinomas.
Skowron MA, Becker TK, Kurz L, Jostes S, Bremmer F, Fronhoffs F, Funke K, Wakileh GA, Müller MR, Burmeister A, Lenz T, Stefanski A, Stühler K, Petzsch P, Köhrer K, Altevogt P, Albers P, Kristiansen G, Schorle H, Nettersheim D. Skowron MA, et al. Mol Oncol. 2022 Feb;16(4):982-1008. doi: 10.1002/1878-0261.13066. Epub 2021 Aug 2. Mol Oncol. 2022. PMID: 34293822 Free PMC article.
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