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Phosphorylation of α-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's disease.
Matsui H, Ito S, Matsui H, Ito J, Gabdulkhaev R, Hirose M, Yamanaka T, Koyama A, Kato T, Tanaka M, Uemura N, Matsui N, Hirokawa S, Yoshihama M, Shimozawa A, Kubo SI, Iwasaki K, Hasegawa M, Takahashi R, Hirai K, Kakita A, Onodera O. Matsui H, et al. Among authors: hasegawa m. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2214652120. doi: 10.1073/pnas.2214652120. Epub 2023 May 30. Proc Natl Acad Sci U S A. 2023. PMID: 37252975 Free PMC article.
alpha-Synuclein is phosphorylated in synucleinopathy lesions.
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. Fujiwara H, et al. Among authors: hasegawa m. Nat Cell Biol. 2002 Feb;4(2):160-4. doi: 10.1038/ncb748. Nat Cell Biol. 2002. PMID: 11813001
Accumulation of phosphorylated alpha-synuclein in aging human brain.
Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S. Saito Y, et al. Among authors: hasegawa m. J Neuropathol Exp Neurol. 2003 Jun;62(6):644-54. doi: 10.1093/jnen/62.6.644. J Neuropathol Exp Neurol. 2003. PMID: 12834109
Phosphorylated α-synuclein in Parkinson's disease.
Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, Hasegawa M, Lin X, Pan C, Galasko D, Goldstein DS, Jensen PH, Yang H, Cain KC, Zhang J. Wang Y, et al. Among authors: hasegawa m. Sci Transl Med. 2012 Feb 15;4(121):121ra20. doi: 10.1126/scitranslmed.3002566. Sci Transl Med. 2012. PMID: 22344688 Free PMC article.
[Alpha-synuclein].
Nonaka T, Hasegawa M. Nonaka T, et al. Among authors: hasegawa m. Nihon Rinsho. 2011 Oct;69 Suppl 8:79-83. Nihon Rinsho. 2011. PMID: 22787758 Japanese. No abstract available.
Prion-like spreading of pathological α-synuclein in brain.
Masuda-Suzukake M, Nonaka T, Hosokawa M, Oikawa T, Arai T, Akiyama H, Mann DM, Hasegawa M. Masuda-Suzukake M, et al. Among authors: hasegawa m. Brain. 2013 Apr;136(Pt 4):1128-38. doi: 10.1093/brain/awt037. Epub 2013 Mar 6. Brain. 2013. PMID: 23466394 Free PMC article.
Pathological alpha-synuclein propagates through neural networks.
Masuda-Suzukake M, Nonaka T, Hosokawa M, Kubo M, Shimozawa A, Akiyama H, Hasegawa M. Masuda-Suzukake M, et al. Among authors: hasegawa m. Acta Neuropathol Commun. 2014 Aug 6;2:88. doi: 10.1186/s40478-014-0088-8. Acta Neuropathol Commun. 2014. PMID: 25095794 Free PMC article.
4,136 results