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Physiologically based pharmacokinetic modeling to predict the impact of liver cirrhosis on glucuronidation via UGT1A4 & UGT2B7/2B4 - a case study with midazolam.
Ozbey AC, Keemink J, Wagner B, Pugliano A, Krähenbühl S, Annaert P, Fowler S, Parrott N, Umehara K. Ozbey AC, et al. Among authors: keemink j. Drug Metab Dispos. 2024 Apr 23:DMD-AR-2023-001635. doi: 10.1124/dmd.123.001635. Online ahead of print. Drug Metab Dispos. 2024. PMID: 38653501 Free article.
Challenges in Permeability Assessment for Oral Drug Product Development.
Koziolek M, Augustijns P, Berger C, Cristofoletti R, Dahlgren D, Keemink J, Matsson P, McCartney F, Metzger M, Mezler M, Niessen J, Polli JE, Vertzoni M, Weitschies W, Dressman J. Koziolek M, et al. Among authors: keemink j. Pharmaceutics. 2023 Sep 28;15(10):2397. doi: 10.3390/pharmaceutics15102397. Pharmaceutics. 2023. PMID: 37896157 Free PMC article. Review.
Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.
Vinarov Z, Abrahamsson B, Artursson P, Batchelor H, Berben P, Bernkop-Schnürch A, Butler J, Ceulemans J, Davies N, Dupont D, Flaten GE, Fotaki N, Griffin BT, Jannin V, Keemink J, Kesisoglou F, Koziolek M, Kuentz M, Mackie A, Meléndez-Martínez AJ, McAllister M, Müllertz A, O'Driscoll CM, Parrott N, Paszkowska J, Pavek P, Porter CJH, Reppas C, Stillhart C, Sugano K, Toader E, Valentová K, Vertzoni M, De Wildt SN, Wilson CG, Augustijns P. Vinarov Z, et al. Among authors: keemink j. Adv Drug Deliv Rev. 2021 Apr;171:289-331. doi: 10.1016/j.addr.2021.02.001. Epub 2021 Feb 18. Adv Drug Deliv Rev. 2021. PMID: 33610694 Free article. Review.
27 results