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Attachment of the RNA degradosome to the bacterial inner cytoplasmic membrane prevents wasteful degradation of rRNA in ribosome assembly intermediates.
Hadjeras L, Bouvier M, Canal I, Poljak L, Morin-Ogier Q, Froment C, Burlet-Schlitz O, Hamouche L, Girbal L, Cocaign-Bousquet M, Carpousis AJ. Hadjeras L, et al. PLoS Biol. 2023 Jan 5;21(1):e3001942. doi: 10.1371/journal.pbio.3001942. eCollection 2023 Jan. PLoS Biol. 2023. PMID: 36603027 Free PMC article.
HRIBO: high-throughput analysis of bacterial ribosome profiling data.
Gelhausen R, Svensson SL, Froschauer K, Heyl F, Hadjeras L, Sharma CM, Eggenhofer F, Backofen R. Gelhausen R, et al. Among authors: hadjeras l. Bioinformatics. 2021 Aug 4;37(14):2061-2063. doi: 10.1093/bioinformatics/btaa959. Bioinformatics. 2021. PMID: 33175953 Free PMC article.
Detachment of the RNA degradosome from the inner membrane of Escherichia coli results in a global slowdown of mRNA degradation, proteolysis of RNase E and increased turnover of ribosome-free transcripts.
Hadjeras L, Poljak L, Bouvier M, Morin-Ogier Q, Canal I, Cocaign-Bousquet M, Girbal L, Carpousis AJ. Hadjeras L, et al. Mol Microbiol. 2019 Jun;111(6):1715-1731. doi: 10.1111/mmi.14248. Epub 2019 Apr 6. Mol Microbiol. 2019. PMID: 30903628 Free PMC article.