King DT - Search Results

1

Potent and Selective Cell-Active Iminosugar Inhibitors of Human α-N-Acetylgalactosaminidase (α-NAGAL).

Ashmus RA, Wang Y, González-Cuesta M, King DT, Tiet B, Chen X, Zhu Y, Kirk B, García Fernandez JM, Ortiz Mellet C, Britton R, Vocadlo DJ. Ashmus RA, et al. Among authors: king dt. Chemistry. 2023 Aug 4;29(44):e202300982. doi: 10.1002/chem.202300982. Epub 2023 Jul 7. Chemistry. 2023. PMID: 37217457

2

Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA).

Ashmus RA, Wang Y, González-Cuesta M, King DT, Tiet B, Gilormini PA, García Fernández JM, Ortiz Mellet C, Britton R, Vocadlo DJ. Ashmus RA, et al. Among authors: king dt. Org Biomol Chem. 2021 Sep 29;19(37):8057-8062. doi: 10.1039/d1ob01526e. Org Biomol Chem. 2021. PMID: 34494637

3

Structural variation of the 3-acetamido-4,5,6-trihydroxyazepane iminosugar through epimerization and C-alkylation leads to low micromolar HexAB and NagZ inhibitors.

Bouquet J, Auberger N, Ashmus R, King D, Bordes A, Fontelle N, Nakagawa S, Madden Z, Proceviat C, Kato A, Désiré J, Vocadlo DJ, Blériot Y. Bouquet J, et al. Org Biomol Chem. 2022 Jan 19;20(3):619-629. doi: 10.1039/d1ob02280f. Org Biomol Chem. 2022. PMID: 34940771

4

Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes.

King DT, Males A, Davies GJ, Vocadlo DJ. King DT, et al. Curr Opin Chem Biol. 2019 Dec;53:131-144. doi: 10.1016/j.cbpa.2019.09.001. Epub 2019 Oct 22. Curr Opin Chem Biol. 2019. PMID: 31654859 Review.

5

The structure of a family 110 glycoside hydrolase provides insight into the hydrolysis of α-1,3-galactosidic linkages in λ-carrageenan and blood group antigens.

McGuire BE, Hettle AG, Vickers C, King DT, Vocadlo DJ, Boraston AB. McGuire BE, et al. Among authors: king dt. J Biol Chem. 2020 Dec 25;295(52):18426-18435. doi: 10.1074/jbc.RA120.015776. Epub 2020 Oct 30. J Biol Chem. 2020. PMID: 33127644 Free PMC article.

6

[No title available]

[No authors listed] [No authors listed] PMID: 33453844

7

Structural and functional insight into human O-GlcNAcase.

Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ. Roth C, et al. Among authors: king dt. Nat Chem Biol. 2017 Jun;13(6):610-612. doi: 10.1038/nchembio.2358. Epub 2017 Mar 27. Nat Chem Biol. 2017. PMID: 28346405 Free PMC article.

8

Multivalency To Inhibit and Discriminate Hexosaminidases.

Alvarez-Dorta D, King DT, Legigan T, Ide D, Adachi I, Deniaud D, Désiré J, Kato A, Vocadlo D, Gouin SG, Blériot Y. Alvarez-Dorta D, et al. Among authors: king dt. Chemistry. 2017 Jul 6;23(38):9022-9025. doi: 10.1002/chem.201701756. Epub 2017 Jun 20. Chemistry. 2017. PMID: 28548311 Free article.

9

Precision Mapping of O-Linked N-Acetylglucosamine Sites in Proteins Using Ultraviolet Photodissociation Mass Spectrometry.

Escobar EE, King DT, Serrano-Negrón JE, Alteen MG, Vocadlo DJ, Brodbelt JS. Escobar EE, et al. Among authors: king dt. J Am Chem Soc. 2020 Jul 1;142(26):11569-11577. doi: 10.1021/jacs.0c04710. Epub 2020 Jun 19. J Am Chem Soc. 2020. PMID: 32510947 Free PMC article.

10

Thermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome.

King DT, Serrano-Negrón JE, Zhu Y, Moore CL, Shoulders MD, Foster LJ, Vocadlo DJ. King DT, et al. J Am Chem Soc. 2022 Mar 9;144(9):3833-3842. doi: 10.1021/jacs.1c10621. Epub 2022 Mar 1. J Am Chem Soc. 2022. PMID: 35230102 Free PMC article.

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