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Page 1
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease.
Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Slow EJ, et al. Among authors: simpson em. Hum Mol Genet. 2003 Jul 1;12(13):1555-67. doi: 10.1093/hmg/ddg169. Hum Mol Genet. 2003. PMID: 12812983
Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities.
Devon RS, Orban PC, Gerrow K, Barbieri MA, Schwab C, Cao LP, Helm JR, Bissada N, Cruz-Aguado R, Davidson TL, Witmer J, Metzler M, Lam CK, Tetzlaff W, Simpson EM, McCaffery JM, El-Husseini AE, Leavitt BR, Hayden MR. Devon RS, et al. Among authors: simpson em. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600. doi: 10.1073/pnas.0510197103. Epub 2006 Jun 12. Proc Natl Acad Sci U S A. 2006. PMID: 16769894 Free PMC article.
Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice.
Schmouth JF, Castellarin M, Laprise S, Banks KG, Bonaguro RJ, McInerny SC, Borretta L, Amirabbasi M, Korecki AJ, Portales-Casamar E, Wilson G, Dreolini L, Jones SJ, Wasserman WW, Goldowitz D, Holt RA, Simpson EM. Schmouth JF, et al. Among authors: simpson em. BMC Biol. 2013 Oct 14;11:106. doi: 10.1186/1741-7007-11-106. BMC Biol. 2013. PMID: 24124870 Free PMC article.
rAAV-compatible MiniPromoters for restricted expression in the brain and eye.
de Leeuw CN, Korecki AJ, Berry GE, Hickmott JW, Lam SL, Lengyell TC, Bonaguro RJ, Borretta LJ, Chopra V, Chou AY, D'Souza CA, Kaspieva O, Laprise S, McInerny SC, Portales-Casamar E, Swanson-Newman MI, Wong K, Yang GS, Zhou M, Jones SJ, Holt RA, Asokan A, Goldowitz D, Wasserman WW, Simpson EM. de Leeuw CN, et al. Among authors: simpson em. Mol Brain. 2016 May 10;9(1):52. doi: 10.1186/s13041-016-0232-4. Mol Brain. 2016. PMID: 27164903 Free PMC article.
PAX6 MiniPromoters drive restricted expression from rAAV in the adult mouse retina.
Hickmott JW, Chen CY, Arenillas DJ, Korecki AJ, Lam SL, Molday LL, Bonaguro RJ, Zhou M, Chou AY, Mathelier A, Boye SL, Hauswirth WW, Molday RS, Wasserman WW, Simpson EM. Hickmott JW, et al. Among authors: simpson em. Mol Ther Methods Clin Dev. 2016 Aug 10;3:16051. doi: 10.1038/mtm.2016.51. eCollection 2016. Mol Ther Methods Clin Dev. 2016. PMID: 27556059 Free PMC article.
HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development.
Connell M, Chen H, Jiang J, Kuan CW, Fotovati A, Chu TL, He Z, Lengyell TC, Li H, Kroll T, Li AM, Goldowitz D, Frappart L, Ploubidou A, Patel MS, Pilarski LM, Simpson EM, Lange PF, Allan DW, Maxwell CA. Connell M, et al. Among authors: simpson em. Elife. 2017 Oct 10;6:e28672. doi: 10.7554/eLife.28672. Elife. 2017. PMID: 28994651 Free PMC article.
New MiniPromoter Ple345 (NEFL) Drives Strong and Specific Expression in Retinal Ganglion Cells of Mouse and Primate Retina.
Simpson EM, Korecki AJ, Fornes O, McGill TJ, Cueva-Vargas JL, Agostinone J, Farkas RA, Hickmott JW, Lam SL, Mathelier A, Renner LM, Stoddard J, Zhou M, Di Polo A, Neuringer M, Wasserman WW. Simpson EM, et al. Hum Gene Ther. 2019 Mar;30(3):257-272. doi: 10.1089/hum.2018.118. Epub 2018 Oct 2. Hum Gene Ther. 2019. PMID: 30062914 Free PMC article.
110 results